5.08150

LY 344864 Hydrochloride

• 동의어(들): LY 344864 Hydrochloride, 5-HT _1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864, 5-HT_1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864
• 실험식(Hill 표기법): C₂₁H₂₂FN₃O · xHCl
• CAS Number: 186544-26-3
• Molecular Weight: 351.42 (free base basis)
• UNSPSC 코드: 12352200

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: water: 10 mM; DMSO: 100 mM
• 저장 온도: 2-8°C
• InChI: 1S/C21H22FN3O.ClH/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13;/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26);1H/t16-;/m1./s1
• InChI key: OKUHLSYESBLBCP-PKLMIRHRSA-N

설명

일반 설명

A selective, brain penetrant, full agonist for the 5-HT_1F receptor (pKi = 8.2). It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT_1F receptors, LY344864 was shown to be a full agonist producing an effect similar in magnitude to serotonin itself. Suitable for both in vitro and in vivo applications and its effects are often reversed with the 5-HT_1B/1D antagonist GR 127935 (Cat. No. 508014)

생화학적/생리학적 작용

Primary Target
5-HT_1F

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Amrutkar, D. V. et al. 2012. Pain.153, 830.

Phebus, L. A. et al. 1997. Life Sci.61, 2117.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable