5.05413

5-Iodo-A-85380 dihydrochloride hydrate

• 동의어(들): 5-Iodo-A-85380 dihydrochloride hydrate, 3-((2S)-2-Azetidinylmethoxy)-5-iodo-pyridine dihydrochloride hydrate, α4β2 and α6β2 Nicotinic Acetylcholine Receptors (nAChR) Agonist, 5-Iodo-A-85380
• 실험식(Hill 표기법): C₉H₁₁IN₂O · 2HCl · xH₂O
• CAS Number: 213550-82-4
• Molecular Weight: 363.02 (anhydrous basis)
• UNSPSC 코드: 12352200

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 양식: powder
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: off-white
• solubility: water: 22 mg/mL
• 저장 온도: 2-8°C
• InChI: 1S/C9H11IN2O/c10-7-3-9(5-11-4-7)13-6-8-1-2-12-8/h3-5,8,12H,1-2,6H2/t8-/m0/s1
• InChI key: RKVRGRXOYDTUEY-QMMMGPOBSA-N

설명

일반 설명

A very potent agonist highly selective for α4β2 and α6β2 nicotinic acetylcholine receptors (nAChR) (K_i= 12 and 10 pM for human and rat α4β2 nAChRs, respectively). An important nAChR ligand for the treatment of pain, smoking addition and other mental disorders.

생화학적/생리학적 작용

Primary Target
α4β2 nAChR

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Liu, X., et al., 2013. Psychopharm.In press.

Kennett, A., et al., 2012. Nicotine Tob. Res.14, 1339.

Huang. LZ, et al., 2011. Neuropharm.60, 861.
Mogg. AJ, et al., 2004. Neuropharm.60, 861.

Mukhin, A.G., et al., 2000. Mol. Pharmacol.47, 848.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable