5.05017

UBP310

• 동의어(들): UBP310, GluK1/GluK3 antagonist, UBP310, (S)-1-(2-Amino-2-carboxyethyl)-3-(2­-carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine­-2,4-dione, UBP-310, UBP 310
• 실험식(Hill 표기법): C₁₄H₁₅N₃O₆S
• CAS Number: 902464-46-4
• Molecular Weight: 353.35
• UNSPSC 코드: 12352200

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 양식: solid
• 효능: 10 nM K_i
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: DMSO: 100 mM
• 저장 온도: 2-8°C
• InChI: 1S/C14H15N3O6S/c1-7-4-16(6-9(15)12(19)20)14(23)17(11(7)18)5-8-2-3-24-10(8)13(21)22/h2-4,9H,5-6,15H2,1H3,(H,19,20)(H,21,22)/t9-/m0/s1
• InChI key: ZTAZUCRXCRXNSU-VIFPVBQESA-N

설명

일반 설명

A potent antagonist highly selective for GluK1 (K_b = 10 nM), GluK3 (IC₅₀ = 23 nM), and GluK1/K5 (K_b = 8 nM) subtype kainate receptors. Does not interact with GluK2 and GluK2/K5 receptors. Low affinity to AMPA receptors (K_d = 83 µM). Does not interact with mGluR1 or NMDA receptors at concentration less than 10 µM. Often used in studying neuronal excitability and synaptic plasticity.

생화학적/생리학적 작용

Primary Target
GluK1

Secondary Target
Gluk3

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Pinheiro, S., et al. 2013. Cereb. Cort.23, 323.
Atlason, T., et al. 2010. Mol. Pharmacol.78, 1036.
Perrais, D., et al. 2009. Neuropharmacol.56, 131.
Dolman, P., et al. 2007. J. Med. Chem.50, 1558.
Mayer, L., et al. 2006. J. Neurosci.26, 2852.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable