A highly selective and potent agonist for recombinant human mGlu2 and mGlu3 receptors (Ki = 149 nM and 92 nM, respectively) and for rat neurons mGlu2/3 receptors (Ki = 88 nM). Negligible interactions with other mGlu receptors and ionotropic glutamate receptors, glutamate transporter subtypes, monoamine and other receptors. Widely used for investigating neuropsychiatric disorders in animal models and developing potential treatment for human mental disorders, such as schizophrenia.
생화학적/생리학적 작용
Primary Target mGlu₂ & mGlu₃
Target Ki: 149 nM and 92 nM for human mGlu₂ and mGlu₃, respectively.
경고
Toxicity: Standard Handling (A)
재구성
Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months ta -20°C.
기타 정보
Seeman, P., 2013. Neuropharmacology.66, 87. Rorick-Kehn, L., et al. 2007. J. Pharmacol. Exp. Ther.321, 308. Fell, M., et al. 2008. J. Pharmacol. Exp. Ther.326, 209. Rodd, Z., et al. 2006. Behav. Brain Res.171, 207. Mezler, M., et al. 2010. Curr. Opi. In Investigational Drugs.11, 833.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.