476480

PKC 20-28, Cell-Permeable, Myristoylated

Pseudosubstrate sequence from protein kinase Cα and β ( PKCα and PKCβ).

• 동의어(들): PKC 20-28, Cell-Permeable, Myristoylated, Myr-N-FARKGALRQ-NH₂, Myristoylated Protein Kinase C Inhibitor 20-28, Cell-Permeable, Protein Kinase C 20-28, Cell-Permeable, Myristoylated, Myristoylated Protein Kinase C Inhibitor 20-28, Cell-Permeable, Myr-N-FARKGALRQ-NH₂, Protein Kinase C 20-28, Cell-Permeable, Myristoylated
• 실험식(Hill 표기법): C₆₀H₁₀₆N₁₈O₁₁
• Molecular Weight: 1255.60
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 형태: lyophilized solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• solubility: water: 10 mg/mL; Tris-HCl, pH 7.5: 25 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

Pseudosubstrate sequence from protein kinase C_α and β ( PKC_α and PKC_β). N-Terminus is myristoylated to allow membrane permeability. Highly specific, reversible, and substrate competitive inhibitor of TPA activation of MARCKS phosphorylation in fibroblast primary cultures (IC₅₀ = 8 µM); exhibits 98% inhibition at 100 µM.

Pseudosubstrate sequence from protein kinase Ca (PKC_α) and PKC_β. N-terminal myristoylated to allow membrane permeability. Highly specific, reversible, and substrate competitive inhibitor of TPA activation of MARCKS phosphorylation in fibroblast primary cultures (IC₅₀ = 8 µM). Exhibits 98% inhibition at 100 µM.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
TPA activation of MARCKS phosphorylation in fibroblast primary cultures

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 8 µM against TPA activation of MARCKS phosphorylation in fibroblast primary cultures

포장

Yes

경고

Toxicity: Standard Handling (A)

서열

N-Myr-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-NH₂

기타 정보

Eichholtz, T., et al. 1993. J. Biol. Chem. 268, 1982.
Ward, N.E. and O’Brian, C.A. 1993. Biochemistry32, 11903.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable