475847

MIF Antagonist IV, RDR 03785

The MIF Antagonist IV, RDR 03785 controls the biological activity of MIF. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 동의어(들): MIF Antagonist IV, RDR 03785, Macrophage Migration Inhibitory Factor Antagonist IV, 6-(Morpholino(4-(trifluoromethyl)phenyl)methyl)-1,3-benzodioxol-5-ol
• 실험식(Hill 표기법): C₁₉H₁₈F₃NO₄
• CAS Number: 289657-30-3
• Molecular Weight: 381.35
• UNSPSC 코드: 12352200
• PubChem Substance ID: 2725942

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: cream
• solubility: DMSO: 50 mg/mL, clear, colorless
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: C1COCCN1C(C2=CC=C(C=C2)C(F)(F)F)C3=CC4=C(C=C3O)OCO4

설명

일반 설명

A cell-permeable morpholino-benzodioxol compound that inhibits MIF tautomerase activity (K_i and IC₅₀ = 0.57 and 2.4 µM, respectively) via direct non-covalent MIF interaction (K_D = 24.5 µM). RDR 03758 at 10 µM is shown to completely neutralize the overriding effect of 100 ng/ml MIF on the inhibition of LPS-stimulated TNF production by dexamethasone (Cat. No. 265005) in RAW 264.7 marcophage cultures.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Ouertatani-Sakouhi, H., et al. 2010. J. Biol. Chem.285, 26581.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable