422625

KLF5 Inhibitor, CID 5951923

The KLF5 Inhibitor, CID 5951923 controls the biological activity of KLF5.

• 동의어(들): KLF5 Inhibitor, CID 5951923, 2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl-(2E)-3-(3-nitrophenyl)prop-2-enoate
• 실험식(Hill 표기법): C₁₆H₁₈N₂O₇S
• CAS Number: 749872-43-3
• Molecular Weight: 382.39
• MDL number: MFCD04796932
• UNSPSC 코드: 12352200
• NACRES: NA.28

속성

• Quality Level: 100
• 분석: ≥99% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: off-white
• solubility: DMSO: 50 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C16H18N2O7S/c1-17(14-7-8-26(23,24)11-14)15(19)10-25-16(20)6-5-12-3-2-4-13(9-12)18(21)22/h2-6,9,14H,7-8,10-11H2,1H3/b6-5+
• InChI key: URVRJYLSUVXWBC-AATRIKPKSA-N

설명

일반 설명

A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC₅₀ = 1.6 µM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr¹⁰⁶⁸ and ERK1/2-Thr²⁰²/Tyr²⁰⁴. Also, up-regulates the phosphorylation of p38 MAPK-Thr¹⁸⁰/Tyr^182.

A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC₅₀ = 1.6 µM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr¹⁰⁶⁸ and ERK1/2-Thr²⁰²/Tyr²⁰⁴. Also, up-regulates the phosphorylation of p38 MAPK-Thr¹⁸⁰/Tyr¹⁸².

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock Solutions are stable for up to 3 months at -20°C.

기타 정보

Bialkowska, A., et al. 2011. Mol. Cancer Ther.10, 2043.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable