420413

Polymyxin B Sulfate, Sterile-Filtered Aqueous Solution, Cell Culture Tested

An antibiotic that inhibits phospholipid sensitive Ca2+-dependent protein kinase.

• 동의어(들): Polymyxin B Sulfate, Sterile-Filtered Aqueous Solution, Cell Culture Tested, Aerosporin, Sterile-Filtered Aqueous Solution, Cell Culture Tested
• CAS Number: 1405-20-5
• MDL number: MFCD00131991
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 양식: liquid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: clear
• 배송 상태: wet ice
• 저장 온도: −20°C
• InChI: 1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
• InChI key: HNDFYNOVSOOGDU-UHFFFAOYSA-N

설명

일반 설명

An antibiotic that inhibits phospholipid sensitive Ca²⁺-dependent protein kinase. Mixture of polymyxin B₁ sulfate and polymyxin B₂ sulfate. Binds to cell wall and makes it more permeable, causing fluid uptake. Effective against Gram-negative bacteria.

생화학적/생리학적 작용

≥7500 units/mg

경고

Toxicity: Harmful (C)

물리적 형태

Supplied at 50 mg/ml in H₂O.

재구성

Following initial thaw, aliquot and freeze (-20°C).

기타 정보

Lucas, M., et al. 1994. Biochem. Pharmacol.47, 667.
Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch.422, 413.
Kubo, M. and Okada, Y. 1992. J. Physiol.456, 351.
Strasser, R.H., et al. 1992. Circ. Res.70, 1304.
Hegemann, L., et al. 1991. Eur. J. Pharmacol.207, 17.
Inaba, H. and Finkins, J.P. 1991. Am. J. Physiol.261, R26.
Marra, M.N., et al. 1990. J. Immunol.144, 662.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable