401490

IKK-2 Inhibitor XI

The IKK-2 Inhibitor XI, also referenced under CAS 354810-80-3, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• 동의어(들): IKK-2 Inhibitor XI, (5-Phenyl-3-ureido)-thiophene-2-carboxamide
• 실험식(Hill 표기법): C₁₂H₁₁N₃O₂S
• CAS Number: 354810-80-3
• Molecular Weight: 261.30
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: off-white
• solubility: DMSO: 10 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C

설명

일반 설명

A cell-permeable thiophenecarboxamide-ureido compound that acts as a potent, ATP-binding pocket-targeting inhibitor of IKK-2 (IC₅₀ = 25 nM), while affecting IKK-1 and JNK1 only at much higher concentrations (IC₅₀ = 1.0 and 1.6 µM, respectively). Shown to reduce LPS-induced TNF-α production in PBMCs (IC₅₀ = 250 nM) and exhibit oral availability with good pharmacokinetic in rats in vivo.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

기타 정보

Baxter, A., et al. 2004. Bioorg. Med. Chem. Lett.14, 2817.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable