382170

Histone Deacetylase Inhibitor IV

The Histone Deacetylase Inhibitor IV, also referenced under CAS 537034-15-4, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 동의어(들): Histone Deacetylase Inhibitor IV, N¹-(2-Aminophenyl)-N⁷-phenylheptanediamide
• 실험식(Hill 표기법): C₁₉H₂₃N₃O₂
• CAS Number: 537034-15-4
• Molecular Weight: 325.40
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: beige
• solubility: DMSO: 100 mg/mL; methanol: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C
• InChI: 1S/C19H23N3O2/c20-16-11-7-8-12-17(16)22-19(24)14-6-2-5-13-18(23)21-15-9-3-1-4-10-15/h1,3-4,7-12H,2,5-6,13-14,20H2,(H,21,23)(H,22,24)
• InChI key: ZAIULUYKQLVQFH-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable pimeloylanilide compound that acts as a FXN- (frataxin gene) specific HDAC (histone deacetylase) inhibitor. Reverses the silencing of FXN transcription in FRDA (Friedreich′s ataxia) cells (~3-fold increase of FXN mRNA at 5 µM in primary FRDA lymphocytes and ~3-fold frataxin expression in FRDA cell line at 2.5 µM) due to hypoacetylation of histones H3 and H4 by increasing acetylation at H3K14, H4K5 and H4K12, without significant changes in acetylation at H3K9, H4K8 and H4K16. In comparison, Trichostatin-A (Cat. No. 647925 and 647926) and SAHA, two other commonly used HDAC inhibitors, exhibit no effect on FXN transcription.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
Histone Deacetylase

Product does not compete with ATP.

Reversible: no

포장

Packaged under inert gas

경고

Toxicity: Harmful (C)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Herman, D., et al. 2006. Nat. Chem. Biol.2, 551.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable