추천 제품
일반 설명
Research area: CELL CYCLE
Recombinant, human androgen receptor (AR) fused at the N-terminus to a Flag-Tag sequence and at the C-terminus to His•Tag sequence, expressed in S. frugiperda insect cells expressed using a baculovirus expression system, and purified by affinity chromatography. It is located at X chromosome and is expressed in various tissues. It consists of three primary functional domains: the N-terminal transcriptional regulation domain, the DNA binding domain (DBD), and the ligand binding domain.
Recombinant, human androgen receptor (AR) fused at the N-terminus to a Flag-Tag sequence and at the C-terminus to His•Tag sequence, expressed in S. frugiperda insect cells expressed using a baculovirus expression system, and purified by affinity chromatography. It is located at X chromosome and is expressed in various tissues. It consists of three primary functional domains: the N-terminal transcriptional regulation domain, the DNA binding domain (DBD), and the ligand binding domain.
생화학적/생리학적 작용
The androgen receptor (AR) has significant biological effects on bone, muscle, prostate, adipose tissue, as well as on the reproductive, cardiovascular, immune, neural, and haemopoietic systems.
The activity of androgen is mediated by the binding of the intracellular androgen receptor which, when activated, translocates to the nucleus and modulates specific gene transcription by interaction with cis-acting hormone response elements in the target genes.
The activity of androgen is mediated by the binding of the intracellular androgen receptor which, when activated, translocates to the nucleus and modulates specific gene transcription by interaction with cis-acting hormone response elements in the target genes.
경고
Toxicity: Standard Handling (A)
단위 정의
1.0 unit is equivalent to 1 ng protein. 20 units are sufficient for a gel-mobility shift assay and 100 units are sufficient for a protein-protein interaction assay.
One unit is defined as 1 ng purified protein.
물리적 형태
In 100 mM KCl, 20 mM Tris-HCl, 1 mM DTT, 200 µM EDTA, 20% glycerol, pH 8.0.
재구성
Following initial thaw, aliquot and freeze (-70°C).
기타 정보
Chen, G., et al. 2005. Prostate63, 395.
Estebanez-Perpina, E., et al. 2005, J. Biol. Chem.280, 8060.
Gao, S., et al. 2005. Mol. Endocrinol.19, 1792.
Hillmer, A.M., et al. 2005. Am. J. Hum. Genet.77, 140.
Kinoshita, M., et al. 2005, Int. J. Urol.12, 390.
Lim, J.T., et al. 2005. Proc. Natl. Acad. Sci. U.S.A.102, 5156;
Marques, R.B., et al. 2005. Int. J. Cancer117, 221;
Metzger, E., et al. 2005. Nature437, 436;
Murthy, S., et al. 2005. Prostate64, 362;
Chang, C., et al. 1992. Proc. Natl. Acad. Sci. USA89, 5946.
Estebanez-Perpina, E., et al. 2005, J. Biol. Chem.280, 8060.
Gao, S., et al. 2005. Mol. Endocrinol.19, 1792.
Hillmer, A.M., et al. 2005. Am. J. Hum. Genet.77, 140.
Kinoshita, M., et al. 2005, Int. J. Urol.12, 390.
Lim, J.T., et al. 2005. Proc. Natl. Acad. Sci. U.S.A.102, 5156;
Marques, R.B., et al. 2005. Int. J. Cancer117, 221;
Metzger, E., et al. 2005. Nature437, 436;
Murthy, S., et al. 2005. Prostate64, 362;
Chang, C., et al. 1992. Proc. Natl. Acad. Sci. USA89, 5946.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
HIS TAG is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Androgen Receptor Structure, Function and Biology: From Bench to Bedside
R Davey and M Grossmann
The Clinical Biochemist. Reviews / Australian Association of Clinical Biochemists, 37(1) , 3?15-3?15 (2016)
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.