341216
NSC668394
≥95% (HPLC), solid, Ezrin inhibitor, Calbiochem®
동의어(들):
Ezrin Inhibitor, NSC668394, 7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione
로그인조직 및 계약 가격 보기
크기 선택
10 MG
₩228,172
₩228,172
예상 입고일2025년 4월 16일세부사항
모든 사진(2)
크기 선택
보기 변경
10 MG
₩228,172
About This Item
실험식(Hill 표기법):
C17H12Br2N2O3
CAS Number:
Molecular Weight:
452.10
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
₩228,172
예상 입고일2025년 4월 16일세부사항
추천 제품
제품명
Ezrin Inhibitor, NSC668394, The Ezrin Inhibitor, NSC668394 controls the biological activity of Ezrin.
Quality Level
분석
≥95% (HPLC)
양식
solid
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
protect from light
색상
red-orange
solubility
DMSO: 50 mg/mL, clear, red-orange
배송 상태
ambient
저장 온도
−20°C
SMILES string
O=C1C=C(NCCC2=CC(Br)=C(O)C(Br)=C2)C(C3=C1C=CC=N3)=O
InChI key
OHPHDPYJEHZGDE-UHFFFAOYSA-N
일반 설명
A cell-permeable, quinoline that binds directly to ezrin (Kd = 12.6 µM) in a reversible manner, and inhibits PKCι-mediated ezrin phosphorylation at Thr567 (IC50 = 8.1 µM) and ezrin-actin binding, in vitro. It also inhibits murine osteosarcoma K7M2 cell invasion in a monolayer of HUVEC cells, dose-dependently, from 1 to 10 µM. At 10 µM, it causes a unique developmental defect in zebrafish, characterized by reduced motility of eye progenitor cells. Furthermore, this small molecule prevents metastatic growth in an ex vivo mouse lung organ culture assay at 10 µM and attenuates ezrin-dependent OS metastatic growth in mouse lung model in vivo at 2.26 mg/kg/day.
포장
Packaged under inert gas
경고
Toxicity: Standard Handling (A)
재구성
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
기타 정보
Bulut, G., et al. 2011. Oncogene31, 269.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
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