324412

Dynamin Inhibitor III, Phthaladyn-23

• 동의어(들): Dynamin Inhibitor III, Phthaladyn-23, 4-Chloro-2-((2-(3-nitrophenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carbonyl)-amino)-benzoic acid
• 실험식(Hill 표기법): C₂₂H₁₂ClN₃O₇
• Molecular Weight: 465.80
• UNSPSC 코드: 12352200
• NACRES: NA.28

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: light yellow to beige
• solubility: DMSO: 7 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C

설명

일반 설명

A cell-permeable phthalimide compound that is reported to inhibit dynamin GTPase activity (IC₅₀ = 17.4 and 63 µM using purified sheep brain dynamin I and recombinant dynamin II, respectively) in a GTP-competitive manner. Shown to block K⁺-induced SVE (synaptic vesicle endocytosis) of FM4-64 dye into rat brain synaptosomes (IC₅₀ = 12.9 µM), while being ineffective at 30 µM against RME (receptor-mediated endocytosis) of transferrin into human osteosarcoma epithelial U2OS cells, presumably due to poor dynamin II inhibitory potency and/or rapid efflux and/or limited permeability in this cell line.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Odell, L.R., et al. 2010. J. Med. Chem.53, 5267.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable