311203

N^G,N^G-Dimethyl-L-arginine, Dihydrochloride

A cell-permeable, reversible inhibitor of nitric oxide synthase in vitro (IC₅₀ = 2-3 µM) and in vivo.

• 동의어(들): ADMA, 2HCl, N^G,N^G-Dimethyl-L-arginine, Dihydrochloride
• 실험식(Hill 표기법): C₈H₁₈N₄O₂ · 2HCl
• CAS Number: 220805-22-1
• Molecular Weight: 275.18
• MDL number: MFCD00270857
• UNSPSC 코드: 12352209
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (TLC)
• 양식: amorphous solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• 색상: white
• solubility: water: 50 mg/mL
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: Cl.Cl.N[C@@H](CCCN=C(N(C)C)N)C(=O)O
• InChI: 1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1
• InChI key: SYLNVYJOPZWPJI-ILKKLZGPSA-N

설명

일반 설명

A cell-permeable, reversible inhibitor of nitric oxide synthase in vitro (IC₅₀ = 2-3 µM) and in vivo. Causes dose-dependent vasoconstriction and bradycardic effects.

Endogenous reversible inhibitor of nitric oxide synthesis in vitro and in vivo. Causes dose-dependent vasoconstriction and bradycardic effects.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
NOS in vitro

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 2-3 µM inhibiting nitric oxide synthase in vitro

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

기타 정보

Closs, E.I., et al. 1997. Nitric Oxide1, 65.
Faraci, F.M., et al. 1995. Am. J. Physiol.269, H1522.
Gardiner, S.M., et al. 1993. Br. J. Pharmacol. 110, 1457.
Kotani, K., et al. 1992. J. Neurochem.58, 1127.
Vallance, P., et al. 1992. Lancet339, 572.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable