309866

Diltiazem, Hydrochloride

Synthetic benzothiazepine that acts as an L-type Ca²⁺ channel antagonist.

• 동의어(들): Diltiazem, Hydrochloride, L-Type Calcium Channel Blocker II
• 실험식(Hill 표기법): C₂₂H₂₆N₂O₄S · xHCl
• CAS Number: 33286-22-5
• Molecular Weight: 414.52 (free base basis)
• MDL number: MFCD00069252
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 설명: Merck USA index - 14, 3202
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• 색상: white
• solubility: water: 50 mg/mL; chloroform: soluble; methanol: soluble
• 배송 상태: ambient
• 저장 온도: 10-30°C
• SMILES string: S1[C@H]([C@H](C(=O)N(c3c1cccc3)CC[N+H](C)C)OC(=O)C)c2ccc(cc2)OC.[Cl-]
• InChI: 1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1
• InChI key: HDRXZJPWHTXQRI-BHDTVMLSSA-N

설명

일반 설명

Synthetic (+)-cis isomer that acts as an L-type Ca²⁺ channel antagonist. Similar in function to nifedipine and verapamil. Has a negative inotropic effect on the heart. Strongly suppresses conductance at the A-V node and automatically at the S-A node. Has also been shown to regulate Ca²⁺ release from intracellular stores in neutrophils.

Synthetic benzothiazepine that acts as an L-type Ca²⁺ channel antagonist. Similar in function to Nifedipine (Cat. No. 481981) and Verapamil (Cat. No. 676777). Has negative inotropic effects on the heart. Strongly suppresses conductance at the A-V node and automaticity at the S-A node. Has also been shown to regulate Ca²⁺ release from intracellular stores in neutrophils.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
L-type Ca2+ channel

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

재구성

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C.

기타 정보

van Zwieten, P.A., and Pfaffendorf, M. 1993. J. Hypertens. Suppl. 11, S3.
Rosales, C., and Brown, E.J. 1992. J. Biol. Chem. 267, 1443.
Julian, D.G. 1987. Am. J. Cardiol. 59, 37J.
Campbell, K.P., et al. 1986. Proc. Natl. Acad. Sci. USA83, 2792.
Gallizzi, J.P., et al. 1986. J. Biol. Chem.261, 1393.
Garcia, M.L., et al. 1986. J. Biol. Chem.261, 8146.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable