239805

Cyclopiazonic Acid, Penicillium cyclopium

A cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca²⁺-ATPase that releases Ca²⁺ from the same intracellular pools as Thapsigargin.

• 동의어(들): Cyclopiazonic Acid, Penicillium cyclopium, CPA
• 실험식(Hill 표기법): C₂₀H₂₀N₂O₃
• CAS Number: 18172-33-3
• Molecular Weight: 336.38
• MDL number: MFCD00167445
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥97% (TLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: off-white
• solubility: DMSO: 1 mg/mL; chloroform: 10 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C
• InChI: 1S/C20H20N2O3/c1-9(23)14-18(24)17-16-11-8-21-13-6-4-5-10(15(11)13)7-12(16)20(2,3)22(17)19(14)25/h4-6,8,12,16-17,21,25H,7H2,1-3H3/t12-,16+,17+/m1/s1
• InChI key: RLOAZVAJNNPPDI-DQYPLSBCSA-N

설명

일반 설명

A cell-permeable, reversible inhibitor of endoplasmic reticulum Ca²⁺-ATPase that releases Ca²⁺ from the same intracellular pools as thapsigargin. Mobilizes Ca²⁺ without increasing the levels of Ins(1,4,5)P₃. Also known to inhibit sarcoplasmic reticular Ca²⁺-ATPase that is distinct from actomyosin ATPase. Bay K 8644 (Cat. No. 196878) can reverse the inhibitory effect of cyclopiazonic acid on the refilling of Ca²⁺ pools that have been depleted by repetitive stimulation with acetylcholine.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
Ca²⁺ uptake in cultured arterial musclue cells

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 560 nM inhibiting Ca2+ uptake in cultured arterial smooth muscle cells

경고

Toxicity: Toxic (F)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Badaoui, A., et al. 1995. J. Mol. Cell. Cardiol. 27, 2495.
Elmoselli, A.B., et al. 1995. Mol. Cell. Biochem. 151, 149.
Schaefer, A., et al. 1994. J. Biol. Chem.269, 8786.
Demaurex, N., et al. 1992. J. Biol. Chem.267, 2318.
Low, A.M., et al. 1992. Am. J. Physiol.262, H31.
Kurebayashi, N., and Ogawa, Y. 1991. J. Muscle Res. Cell Motil.12, 355.
Mason, M.J., et al. 1991. J. Biol. Chem.266, 20856.

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법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H300
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable