231085
Cilostamide
A cell-permeable selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC₅₀ = 70 nM).
동의어(들):
Cilostamide, N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide, OPC 3689
로그인조직 및 계약 가격 보기
모든 사진(1)
About This Item
실험식(Hill 표기법):
C20H26N2O3
CAS Number:
Molecular Weight:
342.43
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (TLC)
형태
solid
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
색상
white
solubility
DMSO: 5 mg/mL
배송 상태
ambient
저장 온도
2-8°C
InChI
1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
InChI key
UIAYVIIHMORPSJ-UHFFFAOYSA-N
일반 설명
A cell-permeable selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 70 nM).
생화학적/생리학적 작용
Cell permeable: yes
Primary Target
PDE 3
PDE 3
Product does not compete with ATP.
Reversible: no
Target IC50: 70 nM against PDE III
경고
Toxicity: Standard Handling (A)
재구성
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
기타 정보
Verghese, M.W., et al. 1995. J. Pharmacol. Exp. Ther. 272, 1313.
Christensen, S.B., and Trophy, T.J. 1994. Ann. Rep. Med. Chem. 29, 185.
Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.
Christensen, S.B., and Trophy, T.J. 1994. Ann. Rep. Med. Chem. 29, 185.
Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Natasja G J Costermans et al.
Journal of visualized experiments : JoVE, (172) (2021-07-06)
Events associated with oocyte nuclear maturation have been well described. However, much less is known about the molecular pathways and processes that take place in the cytoplasm in preparation for fertilization and acquisition of totipotency. During oocyte maturation, changes in
Leen Vanhoutte et al.
Human reproduction (Oxford, England), 22(5), 1239-1246 (2007-02-17)
The use of hormones for controlled ovarian stimulation results in follicular heterogeneity, with oocytes at diverse stages of nuclear and cytoplasmic development. This study evaluated the impact of temporary nuclear arrest by a specific phosphodiesterase 3-inhibitor (PDE3-I), cilostamide, on nuclear
Line M Grønning et al.
FEBS letters, 580(17), 4126-4130 (2006-07-11)
Overexpression of forkhead transcription factor FOXC2 in white adipose tissue (WAT) leads to a lean phenotype resistant to diet-induced obesity. This is due, in part, to enhanced catecholamine-induced cAMP-PKA signaling in FOXC2 transgenic mice. Here we show that rolipram treatment
Chisato Kunitomi et al.
Development (Cambridge, England), 151(11) (2024-05-24)
The RNA-binding protein cytoplasmic polyadenylation element binding 1 (CPEB1) plays a fundamental role in regulating mRNA translation in oocytes. However, the specifics of how and which protein kinase cascades modulate CPEB1 activity are still controversial. Using genetic and pharmacological tools
Xuan G Luong et al.
Nucleic acids research, 48(6), 3257-3276 (2020-01-24)
During oocyte maturation, changes in gene expression depend exclusively on translation and degradation of maternal mRNAs rather than transcription. Execution of this translation program is essential for assembling the molecular machinery required for meiotic progression, fertilization, and embryo development. With
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