218714

Casein Kinase II Inhibitor IX, IQA

The Casein Kinase II Inhibitor IV, also referenced under CAS 391670-48-7, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): Casein Kinase II Inhibitor IX, IQA, 5-Oxo-5,6-dihydroindolo[1,2-a]quinazoline-7-acetic acid
• 실험식(Hill 표기법): C₁₇H₁₂N₂O₃
• CAS Number: 391670-48-7
• Molecular Weight: 292.29
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: light yellow
• solubility: DMSO: 10 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C17H12N2O3/c20-15(21)9-12-10-5-1-3-7-13(10)19-14-8-4-2-6-11(14)17(22)18-16(12)19/h1-8,12H,9H2,(H,20,21)
• InChI key: DNABALWBHCYRNL-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable indoloquinazolinone compound that acts as a potent, selective, and reversible CK2 inhibitor (IC₅₀ = 390 nM with 100 M ATP) in an ATP- and GTP-competitive manner (K_i = 0.17 and 0.21 M, respectively). IQA exhibits much reduced activity against PI 3-Kα/β/γ (No inhibition at 20 M) and 48 commonly studied protein kinases (IC₅₀ ≥10 M with 100 M ATP) and is more selective than TBB (Cat. Nos. 218697 and 218708) with respect to DYRK1a (IC₅₀ = 8 and <1 M, respectively, with 100 M ATP).

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

기타 정보

Piazza, F.A., et al. 2006. Blood108, 1698.
Di Maira, G., et al. 2005. Cell Death Differ.12, 668.
Sarno, S., et al. 2003. Biochem. J.374, 639.
Vangrevelinghe, E., et al. 2003. J. Med. Chem.46, 2656.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable