208750
ALLN
InSolution, ≥95%, Inhibitor of calpain I, calpain II, cathepsin B, and cathepsin L
동의어(들):
InSolution ALLN, Calpain Inhibitor I, LLNL, MG 101, Proteasome Inhibitor V
로그인조직 및 계약 가격 보기
크기 선택
5 MG
₩172,043
₩172,043
예상 입고일2025년 5월 21일세부사항
모든 사진(1)
크기 선택
보기 변경
5 MG
₩172,043
About This Item
실험식(Hill 표기법):
C20H37N3O4
CAS Number:
Molecular Weight:
383.53
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
₩172,043
예상 입고일2025년 5월 21일세부사항
추천 제품
Quality Level
분석
≥95% (HPLC)
양식
solution
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
protect from light
색상
clear colorless
배송 상태
wet ice
저장 온도
−20°C
SMILES string
N([C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C=O)C(=O)[C@@H](NC(=O)C)CC(C)C
InChI
1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1
InChI key
FMYKJLXRRQTBOR-BZSNNMDCSA-N
일반 설명
A 10 mM solution of ALLN (Cat. No. 208719) in anhydrous DMSO. Inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 0.5 nM). Inhibits neutral cysteine proteases and proteasome (Ki = 6 µM). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. Inhibits the proteolysis of IkB-α and IkB-β by the ubiquitin-proteasome complex.
생화학적/생리학적 작용
Cell permeable: yes
Primary Target
calpain 1
calpain 1
Product does not compete with ATP.
Reversible: no
Target Ki: 190 nM, 220 nM, 150 nM, 500 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively
포장
Packaged under inert gas
경고
Toxicity: Flammable (J)
물리적 형태
A 10 mM (5 mg/1.30 ml) solution of ALLN (Cat. No. 208719) in DMSO.
재구성
Following initial thaw, aliquot and freeze (-20°C).
기타 정보
Milligan, S.A., et al. 1996. Arch. Biochem. Biophys.335, 388.
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun.215, 721.
Squier, M.K., et al. 1994. J. Cell Physiol.159, 229.
Rami, J., and Kreiglstein, J. 1993. Brain Res.609, 67.
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun.215, 721.
Squier, M.K., et al. 1994. J. Cell Physiol.159, 229.
Rami, J., and Kreiglstein, J. 1993. Brain Res.609, 67.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
188.6 °F - closed cup
Flash Point (°C)
87 °C - closed cup
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Sergio Castro-Gonzalez et al.
Retrovirology, 18(1), 33-33 (2021-10-30)
Autophagy plays an important role as a cellular defense mechanism against intracellular pathogens, like viruses. Specifically, autophagy orchestrates the recruitment of specialized cargo, including viral components needed for replication, for lysosomal degradation. In addition to this primary role, the cleavage
Allen C T Teng et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(23), 7165-7170 (2015-06-04)
Phospholamban (PLN) is an effective inhibitor of the sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA). Here, we examined PLN stability and degradation in primary cultured mouse neonatal cardiomyocytes (CMNCs) and mouse hearts using immunoblotting, molecular imaging, and [(35)S]methionine pulse-chase experiments, together with
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.
