189400

Aurintricarboxylic Acid

A cell-permeable polyanionic, polyaromatic compound used as a powerful inhibitor of cellular processes that are dependent on the formation of protein-nucleic acid complexes.

• 동의어(들): Aurintricarboxylic Acid, ATA
• 실험식(Hill 표기법): C₂₂H₁₄O₉
• CAS Number: 4431-00-9
• Molecular Weight: 422.34
• MDL number: MFCD00011663
• UNSPSC 코드: 12352106
• NACRES: NA.77

속성

• Quality Level: 100
• 설명: RTECS - GU4790000
• 분석: ≥85% (titration)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: red
• solubility: 0.1 M NaOH: 35 mg/mL
• 배송 상태: ambient
• 저장 온도: 10-30°C
• InChI: 1S/C22H16O9.3H3N/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31;;;/h1-10,19,24-25H,(H,26,27)(H,28,29)(H,30,31);3*1H3
• InChI key: UDPQMNAHKKTHHI-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable polyanionic, polyaromatic compound used as a powerful inhibitor of cellular processes that are dependent on the formation of protein-nucleic acid complexes. Binds to aFGF and reduces its angiogenic activity. Shown to inhibit apoptotic cell death in various cell types induced by a variety of factors. ATA is a potent inhibitor of DNA topoisomerase II (IC₅₀= 75 nM for the yeast enzyme as measured by relaxation assays) that also acts as a potent inhibitor of angiogenesis. Inhibits von Willebrand factor binding to platelets and reduces glutamate-induced neuronal injury. ATA stimulates the tyrosine phosphorylation of MAP kinases, Shc proteins, phosphatidylinositol 3-kinase, and phospholipase Cγ. Inhibits both major calpain isoforms (IC₅₀ = 22 µM and IC₅₀ = 10 µM for µ-calpain and m-calpain, respectively).

Dye content: ~85%.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
DNA topoisomerase 2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 75 nM against DNA topoisomerase II

경고

Toxicity: Irritant (B)

재구성

Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

기타 정보

Lozano, R.M., et al. 1997. Eur. J. Biochem.248, 30.
Benchokroun, Y., et al. 1995. Biochem. Pharmacol.49, 305.
Okada, N., and Koizumi, S. 1995. J. Biol. Chem.270, 16464.
Posner, A., et al. 1995. Biochem. Mol. Biol. Int. 36, 291.
Catchpoole, D.R., et al. 1994. Anticancer Res. 14, 853.
Csernansky, C.A., et al. 1994. J. Neurosci. Res. 38, 101.
Gagliardi, A.R., and Collins, D.C. 1994. Anticancer Res. 14, 475.
Gonzalez, R.G., et al. 1980. Biochemistry19, 4299.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable