182200

βARK1 Inhibitor

The βARK1 Inhibitor, also referenced under CAS 24269-96-3, controls the biological activity of βARK1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): βARK1 Inhibitor, β-Adrenergic Receptor Kinase1 Inhibitor, GRK2 Inhibitor, Methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate
• 실험식(Hill 표기법): C₁₂H₉NO₆
• CAS Number: 24269-96-3
• Molecular Weight: 263.20
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: yellow to orange
• solubility: DMSO: 5 mg/mL; methanol: soluble
• 배송 상태: ambient
• 저장 온도: −20°C
• InChI: 1S/C12H9NO6/c1-17-12(14)10-6-4-8(18-10)2-3-9-5-7-11(19-9)13(15)16/h2-7H,1H3/b3-2+
• InChI key: YDJPHSNZGRVPCK-NSCUHMNNSA-N

설명

일반 설명

A selective inhibitor of β-adrenergic receptor kinase 1 (βARK1) (IC₅₀ = 126 µM). Displays no inhibitory activity against protein kinase A (PKA). Identified from a group of existing compounds (not previously demonstrated to inhibit βARK1) using a two-step rational drug design protocol that included molecular modeling and comparative docking studies. Represents the first inhibitor that distinguishes between βARK1 and PKA, an enzyme with a similar adenine binding pocket. May be useful in the study of mechanisms involved in congestive heart failure where elevated levels of βARK1 desensitize agonist-bound β2-adrenergic receptors.

A selective inhibitor of βARK1 (β-Adrenergic Receptor Kinase 1) (IC₅₀ = 126 µM). Has no inhibitory activity against protein kinase A (PKA).

생화학적/생리학적 작용

Cell permeable: no

Primary Target
βARK1 (β-Adrenergic Receptor Kinase 1)

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 126 µM against βARK1 (β-Adrenergic Receptor Kinase 1)

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Iino, M., et al. 2002. J. Med. Chem.45, 2150.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable