178281

p-APMSF, Hydrochloride

Alternative to DFP and PMSF.

• 동의어(들): p-APMSF, Hydrochloride, p-Amidinophenylmethylsulfonylfluoride, HCl
• CAS Number: 74938-88-8
• MDL number: MFCD00078902
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated
• 색상: white
• solubility: water: 25 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: F[S](=O)(=O)Cc1ccc(cc1)\C(=N\[H])\N.Cl
• InChI: 1S/C8H9FN2O2S.ClH/c9-14(12,13)5-6-1-3-7(4-2-6)8(10)11;/h1-4H,5H2,(H3,10,11);1H
• InChI key: KHLLRHIUKOJXLL-UHFFFAOYSA-N

설명

일반 설명

Alternative to DFP and PMSF. An irreversible inhibitor of trypsin-like serine proteases. Inhibits trypsin and thrombin in equimolar concentration. Acts on C1r, C1s, Factor Xa, and plasmin, requiring a 5- to 10-fold excess for complete irreversible inhibition. Inhibitory activity is approximately 1000-fold greater than that of PMSF.

An alternative to DFP and PMSF. Specific irreversible inhibitor of trypsin-like serine proteases. Inhibits trypsin and thrombin in equimolar concentrations. Acts on C1r, C1s, Factor Xa and plasmin, requiring a 5- to 10-fold excess for complete irreversible inhibition. Inhibitory activity is approximately 1000-fold greater than that of PMSF. Stability is pH dependent: t_½ = 20 min at pH 6.0; 6 min at pH 7.0; 1 millisecond at pH 8.0.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
trypsin-like serine proteases

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Standard Handling (A)

재구성

Unstable in solution; reconstitute just prior to use.

기타 정보

Cole, T.C., et al. 1989. Biochim. Biophys. Acta 990, 254.
Laura, R., et al. 1980. Biochemistry19, 4859.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable