176880
Anisomycin, Streptomyces griseolus
Strongly activates stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase in mammalian cells.
동의어(들):
Anisomycin, Streptomyces griseolus, 2-( p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate, 2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate
로그인조직 및 계약 가격 보기
모든 사진(1)
About This Item
실험식(Hill 표기법):
C14H19NO4
CAS Number:
Molecular Weight:
265.30
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (TLC)
형태
solid
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
색상
white
solubility
DMSO: 100 mg/mL
methanol: 50 mg/mL
배송 상태
ambient
저장 온도
2-8°C
InChI
1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m0/s1
InChI key
YKJYKKNCCRKFSL-BFHYXJOUSA-N
일반 설명
Activates p54 and MAP kinases. Involved in the activation of stress-activated protein kinases (SAPKs). Synergizes with growth factors to induce c-fos and c-jun by acting as a potent signaling agonist. An inhibitor of protein synthesis at the translation step. Also known to induce apoptosis in the human monoblastoid cell line, U937.
Strongly activates stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase in mammalian cells. Synergizes with growth factors to induce c-fos and c-jun by acting as a potent signaling agonist. An inhibitor of protein synthesis at the translation step. Also known to induce apoptosis in the human monoblastoid cell line, U937.
경고
Toxicity: Toxic (F)
재구성
Following reconstitution store in the refrigerator (4°C). DMSO stock solutions are stable for up to 6 months at 4°C.
기타 정보
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Hazzalin, C.A., et al. 1998. Mol. Cell. Biol. 18, 1844.
Kardalinou, E., et al. 1994. Mol. Cell. Biol.14, 1066.
Kyriakis, J.M., et al. 1994. Nature 369, 156.
Sanchez, I., et al. 1994. Nature 372, 794.
Shinohara, K., and Oka, T. 1994. NeuroReport 5, 2201.
Kochi, S. K., and Collier, R.J. 1993. Exp. Cell Res.208, 296.
Kardalinou, E., et al. 1994. Mol. Cell. Biol.14, 1066.
Kyriakis, J.M., et al. 1994. Nature 369, 156.
Sanchez, I., et al. 1994. Nature 372, 794.
Shinohara, K., and Oka, T. 1994. NeuroReport 5, 2201.
Kochi, S. K., and Collier, R.J. 1993. Exp. Cell Res.208, 296.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 3 Oral
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
James L McLellan et al.
Life science alliance, 7(6) (2024-04-05)
Increasing numbers of antimalarial compounds are being identified that converge mechanistically at inhibition of cytoplasmic translation, regardless of the molecular target or mechanism. A deeper understanding of how their effectiveness as liver stage translation inhibitors relates to their chemoprotective potential
Madeleine Scharf et al.
Molecular and cellular biology, 33(13), 2586-2602 (2013-04-24)
The mitogen-activated protein kinase (MAPK)-activated protein kinases 2 and 3 (MK2/3) represent protein kinases downstream of the p38 MAPK. Using MK2/3 double-knockout (MK2/3(-/-)) mice, we analyzed the role of MK2/3 in cross-striated muscle by transcriptome and proteome analyses and by
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Major depressive disorder (MDD) is a devastating condition. Although progress has been made in the past seven decades, patients with MDD continue to receive an inadequate treatment, primarily due to the late onset of first-line antidepressant drugs and to their
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In neurons, the endoplasmic reticulum (ER) forms a highly dynamic network that enters axons and presynaptic terminals and plays a central role in Ca2+ homeostasis and synapse maintenance; however, the underlying mechanisms involved in regulation of its dynamic remodeling as
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