14-923-M

Flt1 Protein, active, 10 µg

Active, N-terminal GST-tagged, recombinant, human Flt1, amino acids 783-end. For use in Kinase Assays.

• UNSPSC 코드: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

속성

• 생물학적 소스: human
• Quality Level: 100; 300
• 재조합: expressed in baculovirus infected Sf21 cells
• 분자량: M_w 89 kDa
• 제조업체/상표: Upstate^®
• 기술: activity assay: suitable (kinase)
• GenBank 수납 번호: AF063657
• UniProt 수납 번호: P17948

설명

일반 설명

Product Source: N-terminal GST-tagged, recombinant, human Flt1 amino acids 783-end, expressed by baculovirus in Sf21 insect cells.

This protein encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.

애플리케이션

Research Category
Signaling

생화학적/생리학적 작용

Protein Target: Flt1

Target Sub-Family: TK

포장

Also available in 250μg size as catalog # 14-923M and in bulk as catalog # 14-923-K.

품질

Routinely evaluated by phosphorylation of peptide KKKSPGEYVNIEFG

물리적 형태

50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.

Purified using glutathione sepharose.

저장 및 안정성

6 months at -70°C

기타 정보

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

법적 정보

GenBank is a registered trademark of United States Department of Health and Human Services

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H317
• 예방조치 성명서: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable