14-522-M

ABL (T315I) Protein, active

recombinant, expressed in baculovirus infected Sf21 cells

• UNSPSC 코드: 12352200
• eCl@ss: 32160405
• NACRES: NA.41

속성

• product name: Abl (T315I) Protein, active, 10 µg, Active, N-terminal His6-tagged recombinant human Abl, residues 27-end containing the T315I mutation. For use in Kinase Assays.
• 생물학적 소스: human
• 재조합: expressed in baculovirus infected Sf21 cells
• 분자량: M_w 121 kDa
• 제조업체/상표: Upstate^®
• 기술: activity assay: suitable (kinase)
• NCBI 수납 번호: NM_005157.3; NM_007313.2
• UniProt 수납 번호: P00519

설명

일반 설명

N-terminal His6-tagged recombinant human Abl, residues 27-end containing the T315I mutation

Contains the gatekeeper mutation T315I in the ATP-binding domain. This mutation decreases the sensitivity to Gleevec by more than 200-fold as compared to the wild type sequence.

Product Source: Expressed by baculovirus in Sf21 insect cells

애플리케이션

Research Category
Metabolism

Inflammation & Immunology

Research Sub Category
Obesity

Metabolic Disorders

Osteoporosis

Arthritis

생화학적/생리학적 작용

Protein Target: Abl

Target Sub-Family: TK

포장

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-522M when ordering the 250 µg size.

품질

routinely evaluated by phosphorylation of Abltide

물리적 형태

Ni²⁺/NTA-agarose

저장 및 안정성

6 months at -70°C

기타 정보

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.