14-347-M

CHK2 Protein, active, 10 µg

Active, recombinant human CHK2, residues 5-543, containing N-terminal GST & C-terminal His-6 tags, for use in Kinase Assays.

• UNSPSC 코드: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

속성

• 생물학적 소스: human
• Quality Level: 100
• 재조합: expressed in E. coli
• 제품 라인: Upstate^®
• 특이 활성도: (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
• 분자량: M_w 89.6 kDa
• 정제법: (glutathione-agarose and Ni²⁺/NTA-agarose)
• 종 반응성: human
• 제조업체/상표: Upstate^®
• 기술: activity assay: suitable (kinase)
• 수납 번호(accession number): (FUNCTION: SwissProt: O96017 # Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on ′Ser-216′, preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at ′Thr-18′ and ′Ser-20′. ); NM_001005735.1
• NCBI 수납 번호: NM_001005735.1; NM_007194.3; NM_145862.2
• UniProt 수납 번호: O96017
• 유전자 정보: human ... CHEK2(11200)

설명

일반 설명

Recombinant human CHK2, residues 5-543, containing N-terminal GST and Cterminal His6 tags

생화학적/생리학적 작용

Protein Target: CHK2

Target Sub-Family: CAMK

포장

Also available in 10 μg size and in bulk

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-347M when ordering the 250 µg size.

품질

routinely evaluated by phosphorylation of the CHKtide substrate peptide

표적 설명

CHK2

물리적 형태

glutathione-agarose and Ni²⁺/NTA-agarose

저장 및 안정성

1 year at -70°C

기타 정보

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H317
• 예방조치 성명서: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°C): Not applicable