138000

D-Amino Acid Oxidase Inhibitor

The D-Amino Acid Oxidase Inhibitor, also referenced under CAS 39793-31-2, controls the biological activity of D-Amino Acid Oxidase.

• 동의어(들): D-Amino Acid Oxidase Inhibitor, 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, D-AAO Inhibitor, Compound 8
• 실험식(Hill 표기법): C₇H₅NO₂S
• CAS Number: 39793-31-2
• Molecular Weight: 167.19
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: beige
• solubility: 5% NaOH: 25 mg/mL; DMSO: 80 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10)
• InChI key: PMHDSACGRKBACK-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable thienopyrrole compound that potently inhibits the cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC₅₀ against human and rat DAO = 145 and 114 nM, respectively), while exhibiting no activity towards D-aspartate oxidase (DDO; IC₅₀ >5 µM), P450 enzymes CYP3A4/2D6/3C9 (IC₅₀ >10 µM), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.

포장

Packaged under inert gas

경고

Toxicity: Harmful (C)

재구성

Unstable in solution; reconstitute just prior to use.

기타 정보

Smith, S.M., et al. 2009. J. Pharmacol. Exp. Ther.328, 921.
Sparey, T., et al. 2008. Bioorg. Med. Chem. Lett.18, 3386.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable