119135

Adenosine A1 Receptor Agonist I, CPA

• 동의어(들): Adenosine A1 Receptor Agonist I, CPA
• 실험식(Hill 표기법): C₁₅H₂₁N₅O₄
• CAS Number: 41552-82-3
• Molecular Weight: 335.36
• MDL number: MFCD00036845
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥99% (HPLC)
• Quality Level: 100
• 양식: solid
• 효능: 0.8 nM K_i
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: 1 M HCl: 100 mM; DMSO: 100 mM; ethanol: 25 mM
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: [n]2(c3ncnc(c3nc2)NC4CCCC4)C1O[C@@H]([C@H]([C@H]1O)O)CO
• InChI: 1S/C15H21N5O4/c21-5-9-11(22)12(23)15(24-9)20-7-18-10-13(16-6-17-14(10)20)19-8-3-1-2-4-8/h6-9,11-12,15,21-23H,1-5H2,(H,16,17,19)/t9-,11-,12-,15?/m1/s1
• InChI key: SQMWSBKSHWARHU-FJFSNTMWSA-N

설명

일반 설명

A potent and selective agonist of adenosine A1 receptor (A1R) (K_i = 2.3 nM, 790 nM, 18.6 µM, 43nM for human A1, A2A, A2B, and A3, respectively).

생화학적/생리학적 작용

Primary Target
A1

Reversible: yes

경고

Toxicity: Standard Handling (A)

제조 메모

slight warming is required for complete solubilization in ethanol

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Migita, H., et al. 2008. J Neurosci Res.86, 2820.
Burgdorf, C. et al. 2005. J Cardiovasc Pharmacol.45, 1.
Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.
Mironov, S., et al. 1990. J Neurophysiol.81, 1.
Monopoli, A., et al. 1994. Arzneimittelforschung.44, 1305.
Concas, A., et al. 1993. J Pharmacol Exp Ther.267, 844.
Lohse, M. J., et al. 1988. Nauryn Schmiedebergs Arch Pharmacol.337, 687.
Coffin, V. L., et al. 1987. J Pharmacol Exp Ther.241, 76.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable