1.00242

Citric acid monohydrate

crystalline, EMPROVE^® ESSENTIAL, Ph. Eur., BP, ChP, USP, FCC, E 330

• 동의어(들): 2-Hydroxypropane-1,2,3-tricarboxylic acid, Hydroxytricarballylic acid
• Linear Formula: HOC(COOH)(CH₂COOH)₂ · H₂O
• CAS Number: 5949-29-1
• Molecular Weight: 210.14
• Beilstein: 4018641
• MDL number: MFCD00149972
• UNSPSC 코드: 12352106
• E 번호: E330
• EC 인덱스 번호: 201-069-1

속성

• Agency: BP; ChP; Ph. Eur.; USP
• Quality Level: 500
• 규정 준수: FCC
• vapor pressure: <1 Pa ( 25 °C)
• 설명: cryst. EMPROVE^® ESSENTIAL Ph Eur,BP,JP,USP,E 330,FCC
• 제품 라인: EMPROVE^® ESSENTIAL
• 형태: coarse powder; crystalline
• 효능: 3000 mg/kg LD₅₀, oral (Rat)
• pH: 1.85 (25 °C, 50 g/L in H₂O)
• pKa: (1) 3.13, (2) 4.76, (3) 6.4
• mp: 135-152 °C
• 전이 온도: flash point 173.9 °C
• solubility: 880 g/L
• density: 1.54 g/cm³ at 20 °C
• 응용 분야: liquid formulation; ophthalmics; pharmaceutical; semi-solid formulation; solid formulation
• 저장 온도: 2-30°C
• SMILES string: OC(CC(O)(C(O)=O)CC(O)=O)=O.O
• InChI: 1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2
• InChI key: YASYEJJMZJALEJ-UHFFFAOYSA-N

설명

일반 설명

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

애플리케이션

Citric acid is typically used as pH adjuster, buffer agent or as antioxidant in pharmaceutical formulations. Its application range spans across different formulation types, including semi-solid dosage forms, liquid dosage forms such as solutions and solid dosage forms such as effervescent tablets or granules.
Citric acid monohydrate cryst. Emprove^® Essential is citric acid present in its crystalline monohydrate form.

법적 정보

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): 345.0 °F - closed cup
• Flash Point (°C): 173.9 °C - closed cup