09-466

Anti-phospho-CrkL (Tyr207) Antibody

Upstate^®, from rabbit

• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: mouse, rat, human
• 제조업체/상표: Upstate^®
• 기술: western blot: suitable
• NCBI 수납 번호: NP_005198
• UniProt 수납 번호: P46109
• 배송 상태: dry ice
• 타겟 번역 후 변형: phosphorylation (pTyr207)
• 유전자 정보: human ... CRKL(1399)

설명

일반 설명

CRKL belongs to a family of adaptor proteins containing SH2/SH3 domains that couple to effector proteins including p130CAS, SOS, Abl, and Arg. CRKL plays a role in the mediation of Integrin- and Rac-dependent cell migration and in Ras-dependent activation of JNK. The protein is also involved in T-cell activation. Phosphorylation of CrkL on Tyr207 is known to be correlated with its inhibition.

특이성

Recognizes CrkL only when phosphorylated on Tyr207.

면역원

KLH synthetic peptide including and encompassing Tyr 207 of human CrkL.

애플리케이션

Detect phospho-CrkL (Tyr207) using this Anti-phospho-CrkL (Tyr207) Antibody validated for use in WB.

Research Category
Signaling

Research Sub Category
Cytoskeletal Signaling

품질

Routinely evaluated by western blot on K563 cell lysates.

표적 설명

39 kDa

물리적 형태

Purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide in 50% glycerol.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

분석 메모

Control
K562

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2