07-2178

Anti-Abl interactor 1 Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): Abl interactor 1, Abelson interactor 1, Abi-1, Abl-binding protein 4, AblBP4, Eps8 SH3 domain-binding protein, Eps8-binding protein, Nap1-binding protein, Nap1BP, Spectrin SH3 domain-binding protein 1, e3B1
• UNSPSC 코드: 12352203
• eCl@ss: 32160702

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: human, mouse
• 종 반응성(상동성에 의해 예측): rat (based on 100% sequence homology), bovine (based on 100% sequence homology)
• 기술: western blot: suitable
• NCBI 수납 번호: NP_005461
• UniProt 수납 번호: Q8IZP0
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: bovine ... Abi1(540815) ; human ... ABI1(10006) ; mouse ... Abi1(11308) ; rat ... Abi1(79249)

설명

일반 설명

Abl interactor 1 (Abelson interactor 1) is a member of the family of Abl-interactors and is highly expressed in the brain. Abl interactor 1 is involved in the signaling of ABL1 and ABL2 nonreceptor tyrosine kinases, and the EGF-receptor. The Abl interactor 1 protein contains SH3 domains, and may function as an adaptor protein; It forms a trimeric complex with EPS8 and SOS1 in the transduction of signals from Ras to Rac. Previous studies have suggested that Abl interactor 1 via the Ras and Rac pathways may regulate cell proliferation, cell adhesion, and actin remodeling. Abl interactor 1 is also investigated for its role in tumor suppression.

면역원

KLH-conjugated linear peptide corresponding to human Abl interactor 1.

애플리케이션

Detect Abl interactor 1 using this Anti-Abl interactor 1 Antibody validated for use in Western Blotting.

Research Category
Signaling

Research Sub Category
Developmental Signaling

품질

Evaluated by Western Blot in Jurkat cell lysate.

Western Blot Analysis: A 1:1,000 dilution of this antibody detected Abl interactor 1 on 10 µg of Jurkat cell lysate.

표적 설명

~60 kDa observed. Uniprot describes many isoforms between 43-55 kDa that can be highly phosphorylated.

물리적 형태

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
Jurkat cell lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable