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Merck
모든 사진(1)

주요 문서

06-1365

Sigma-Aldrich

Anti-SRp40 Antibody

from rabbit

동의어(들):

serine/arginine-rich splicing factor 5, Pre-mRNA-splicing factor SRP40, Delayed-early protein HRS, SR splicing factor 5, splicing factor, arginine/serine-rich 5

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About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41
제품 06-1365은(는)귀하의 국가에서 현재 판매되지 않습니다. 고객지원팀으로 연락바랍니다.

생물학적 소스

rabbit

Quality Level

항체 형태

purified antibody

항체 생산 유형

primary antibodies

클론

polyclonal

종 반응성

human, mouse

기술

immunoprecipitation (IP): suitable
western blot: suitable

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

타겟 번역 후 변형

unmodified

유전자 정보

human ... SRSF5(6430)

일반 설명

SRp40 is a nuclear phosphoprotein that is a member of the SR family of proteins. Essential for alternative splicing regulation this protein is also known as Serine/arginine-rich splicing factor 5, and Delayed-early protein HRS. The SRp40 protein is a component of the spliceosome complex and appears to play a role in splice site selection. Over-expression of SRp40 is thought to cause increased chondrogenic differentiation of mesenchymal cells. In addition, increased expression of SRp40 has been found in breast tumor tissues and is associated with alternative pre-mRNA splicing of CD44.

면역원

Linear peptide corresponding to human SRp40.

애플리케이션

Immunoprecipitation Analysis:
A representative lot was used by an independent laboratory in IP. (Jiang, K., et al. (2009). Endocrinology. 150(5):2087-2097.)
Research Category
Epigenetics & Nuclear Function
Research Sub Category
RNA Metabolism & Binding Proteins
Use Anti-SRp40 Antibody (Rabbit Polyclonal Antibody) validated in WB, IP to detect SRp40 also known as serine/arginine-rich splicing factor 5, Pre-mRNA-splicing factor SRP40.

품질

Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 1:500 dilution of this antibody detected SRp40 on 10 µg of HeLa cell lysate.

표적 설명

~38 kDa observed

물리적 형태

Format: Purified
Protein A
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
HeLa cell lysate

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Petar N Grozdanov et al.
Biology of reproduction, 94(2), 34-34 (2015-12-25)
Spermatogenesis is coordinated by the spatial and temporal expression of many transcriptional and posttranscriptional factors. The cyclic AMP-responsive element modulator (CREM) gene encodes both activator and repressor isoforms that act as transcription factors to regulate spermiogenesis. We found that the
Amita Vaidya et al.
Cells, 9(8) (2020-08-07)
Breast tumor heterogeneity is a major impediment to oncotherapy. Cancer cells undergo rapid clonal evolution, thereby acquiring significant growth and invasive advantages. The absence of specific markers of these high-risk populations precludes efficient therapeutic and diagnostic management of the disease.
Stretching muscle cells induces transcriptional and splicing transitions and changes in SR proteins.
Hinkle, et al.
Communications biology, 5, 987-987 (2022)

질문

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