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LM4113

Avanti

25-hydroxycholesterol (D6)

Avanti Research™ - A Croda Brand

동의어(들):

cholest-5-ene-3β,25-diol(d6)

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C27H40D6O2
CAS Number:
88247-69-2
Molecular Weight:
408.69
UNSPSC 코드:
12352100
NACRES:
NA.25

양식

methanol solution

포장

pkg of 1 × 1 mL (LM4113-1EA)

제조업체/상표

Avanti Research™ - A Croda Brand

농도

~10 μg/mL (Refer to C of A for lot specific concentration. )

응용 분야

lipidomics
metabolomics

배송 상태

dry ice

저장 온도

−20°C

SMILES string

[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC(O)(C([2H])([2H])[2H])C([2H])([2H])[2H]

InChI

1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1/i2D3,3D3

InChI key

INBGSXNNRGWLJU-KHKDDIDZSA-N

일반 설명

25-hydroxycholesterol is an oxygenated sterol[1] and a hydroxylated derivative of cholesterol.[2]

생화학적/생리학적 작용

25-hydroxycholesterol inhibits cholesterol biosynthesis by downregulating the function of 3-hydroxy-3-methylglutaryl-CoA reductase.[1] It is found to be implicated in atherosclerosis. 25-hydroxycholesterol levels are known to be increased in hypercholesterolemic condition.[2]

포장

2 mL Amber Glass Sealed Ampule (LM4113-1EA)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

픽토그램

FlameSkull and crossbonesHealth hazard
GHS02,GHS06,GHS08

신호어

Danger

유해 및 위험 성명서

H225,H301 + H311 + H331,H370

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

표적 기관

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point (°F)

49.5 °F - closed cup

Flash Point (°C)

9.7 °C - closed cup

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Christopher M Adams et al.
The Journal of biological chemistry, 279(50), 52772-52780 (2004-09-29)
The current paper demonstrates that cholesterol and its hydroxylated derivative, 25-hydroxycholesterol (25-HC), inhibit cholesterol synthesis by two different mechanisms, both involving the proteins that control sterol regulatory element-binding proteins (SREBPs), membrane-bound transcription factors that activate genes encoding enzymes of lipid
Rosamaria Lappano et al.
PloS one, 6(1), e16631-e16631 (2011-02-10)
The hydroxylated derivatives of cholesterol, such as the oxysterols, play important roles in lipid metabolism. In particular, 25-hydroxycholesterol (25 HC) has been implicated in a variety of metabolic events including cholesterol homeostasis and atherosclerosis. 25 HC is detectable in human
Cholsoon Jang et al.
Nature medicine, 22(4), 421-426 (2016-03-08)
Epidemiological and experimental data implicate branched-chain amino acids (BCAAs) in the development of insulin resistance, but the mechanisms that underlie this link remain unclear. Insulin resistance in skeletal muscle stems from the excess accumulation of lipid species, a process that
Ken Cheng et al.
Journal of agricultural and food chemistry, 66(33), 8876-8884 (2018-07-26)
Membrane lipids, including sphingolipids and glycerol-phospholipids, are essential in maintaining the skin's barrier function in mammals, but their composition in fish skin and their response to diets have not been evaluated. This study investigated the impacts of reducing dietary eicosapentaenoic

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