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870708P

Avanti

08:0 Coenzyme A

Avanti Research™ - A Croda Brand 870708P, powder

동의어(들):

octanoyl Coenzyme A (ammonium salt)

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크기 선택

5 MG
₩616,816

₩616,816

구입 가능 여부는 고객센터에 문의하십시오.
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모든 사진(1)

크기 선택

보기 변경
5 MG
₩616,816

About This Item

실험식(Hill 표기법):
C29H59N10O17P3S
CAS Number:
799812-82-1
Molecular Weight:
944.82
UNSPSC 코드:
12352211
NACRES:
NA.25

₩616,816

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청

양식

powder

포장

pkg of 1 × 5 mg (870708P-5mg)

제조업체/상표

Avanti Research™ - A Croda Brand 870708P

응용 분야

lipidomics

지질 유형

coenzymes

배송 상태

dry ice

저장 온도

−20°C

SMILES string

O[C@@](C(NCCC(NCCSC(CCCCCCC)=O)=O)=O)(C(C)(COP([O-])(OP([O-])(OC[C@H]([C@H]1OP([O-])(O)=O)O[C@H]([C@@H]1O)N2C3=C(C(N)=NC=N3)N=C2)=O)=O)C)[H].[NH4+].[NH4+].[NH4+]

InChI

1S/C29H50N7O17P3S.3H3N/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36;;;/h16-18,22-24,28,39-40H,4-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44);3*1H3/t18-,22?,23+,24+,28-;;;/m1.../s1

InChI key

FTIQWXKUZWNHGD-DMTDIVBASA-N

일반 설명

08:0 Coenzyme A, also referred as octanoyl Coenzyme A, is a medium-chain acyl CoA.[1] It is a coenzyme A derivative of octanoic acid.

애플리케이션

08:0 Coenzyme A has been used as a substrate in microsomal ghrelin octanoyltransferase assay.[2]

생화학적/생리학적 작용

08:0 Coenzyme A acts as an intermediate in mitochondrial fatty acid β-oxidation.[3] It hinders the activity of citrate synthase (CS) and glutamate dehydrogenase (GDH).[1] Higher levels of octanoyl –CoA, due to reduced β-oxidation of octanoyl-CoA by medium-chain acyl CoA dehydrogenase (MCADH), is observed in patients with MCADH deficiency (MCD).[4][3]

포장

5 mL Amber Glass Screw Cap Vial (870708P-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

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시험 성적서(COA)

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문서 라이브러리 방문

Robert Modre-Osprian et al.
BMC systems biology, 3, 2-2 (2009-01-08)
The oxidation of fatty acids in mitochondria plays an important role in energy metabolism and genetic disorders of this pathway may cause metabolic diseases. Enzyme deficiencies can block the metabolism at defined reactions in the mitochondrion and lead to accumulation
B A Amendt et al.
The Journal of clinical investigation, 76(3), 963-969 (1985-09-01)
Medium-chain acyl-coenzyme A (CoA) dehydrogenase (MCADH; EC 1.3.99.3) deficiency (MCD) is an inborn error of beta-oxidation. We measured 3H2O formed by the dehydrogenation of [2,3-3H]acyl-CoAs in a 3H-release assay. Short-chain acyl-CoA dehydrogenase (SCADH; EC 1.3.99.2), MCADH, and isovaleryl-CoA dehydrogenase (IVDH;
J C Lai et al.
Research communications in chemical pathology and pharmacology, 82(3), 331-338 (1993-12-01)
We investigated the hypothesis that one mechanism underlying fatty acid toxicity is the selective inhibition of rate-limiting and/or regulated tricarboxylic acid cycle and related enzymes by fatty acyl coenzyme A (CoA) derivatives by examining the effects of several fatty acyl
Martin S Taylor et al.
Bioorganic chemistry, 62, 64-73 (2015-08-08)
Ghrelin-O-Acyltransferase (GOAT) is an 11-transmembrane integral membrane protein that octanoylates the metabolism-regulating peptide hormone ghrelin at Ser3 and may represent an attractive target for the treatment of type II diabetes and the metabolic syndrome. Protein octanoylation is unique to ghrelin

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