추천 제품
형태
liquid
포장
pkg of 1 × 1 mL (870600C-1mg)
제조업체/상표
Avanti Research™ - A Croda Brand 870600C
농도
1 mg/mL (870600C-1mg)
배송 상태
dry ice
저장 온도
−20°C
SMILES string
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCC(O)=O)=O)COC(CCCCCCCCCCCCCCC)=O)=O
일반 설명
1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine (PAzePC) has carboxyl groups at the end of their truncated sn-2 chains.
애플리케이션
1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine (PAzePC) may be used:,as an oxidized lipid dopant in liposomes for investigating the relationship between the permeation of H2O2 and the structure of lipid membranes, as a substrate for lysosomal phospholipase A2 during the study of structural basis of lysosomal phospholipase A2 inhibition by Zn2+, in the preparation of large unilamellar vesicles (LUVs) and giant unilamellar vesicles (GUVs).
생화학적/생리학적 작용
1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine (PAzePC) is an oxidized lipid. PAzePC acts as an inter- H2O2 permeation promoter. It serves as a drug target for antipsychotic drugs and antimicrobial agents in cells under oxidative stress at inflammatory sites. PAzePC facilitates permeabilization of Bax associated-mitochondrial membranes under oxidative stress.
포장
5 mL Clear Glass Sealed Ampule (870600C-1mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
표적 기관
Central nervous system, Liver,Kidney
Storage Class Code
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
Flash Point (°F)
does not flash
Flash Point (°C)
does not flash
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Martin Lidman et al.
Biochimica et biophysica acta, 1858(6), 1288-1297 (2016-03-08)
Mitochondria play a crucial role in programmed cell death via the intrinsic apoptotic pathway, which is tightly regulated by the B-cell CLL/lymphoma-2 (Bcl-2) protein family. Intracellular oxidative stress causes the translocation of Bax, a pro-apoptotic family member, to the mitochondrial
Himanshu Khandelia et al.
Biophysical journal, 96(7), 2734-2743 (2009-04-08)
In oxidative environments, biomembranes contain oxidized lipids with short, polar acyl chains. Two stable lipid oxidation products are PoxnoPC and PazePC. PoxnoPC has a carbonyl group, and PazePC has an anionic carboxyl group pendant at the end of the short
Renee A Bouley et al.
Biochemistry, 58(13), 1709-1717 (2019-03-05)
Lysosomal phospholipase A2 (LPLA2/PLA2G15) is a key enzyme involved in lipid homeostasis and is characterized by both phospholipase A2 and transacylase activity and by an acidic pH optimum. Divalent cations such as Ca2+ and Mg2+ have previously been shown to
Yuya Ouchi et al.
Scientific reports, 9(1), 12497-12497 (2019-08-31)
H2O2 permeation through a cell membrane significantly affects living organisms, and permeation is controlled by the physico-chemical nature of lipids and other membrane components. We investigated the molecular relationship between H2O2 permeation and lipid membrane structure using three oxidized lipids.
Mooud Amirkavei et al.
Biochimica et biophysica acta, 1858(2), 264-273 (2015-12-15)
In order to obtain molecular level insight into the biophysics of the apoptosis promoting phospholipid 1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine (PazePC) we studied its partitioning into different lipid phases by isothermal titration calorimetry (ITC). To aid the interpretation of these data for PazePC, we
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