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860478P

Avanti

cis-4-methylsphingosine

Avanti Research™ - A Croda Brand

동의어(들):

5-Nonadecene-1,4-diol, 3-amino-5-methyl-, (3R,4S,5Z)-

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크기 선택

5 MG
₩228,680

₩228,680

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모든 사진(1)

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5 MG
₩228,680

About This Item

실험식(Hill 표기법):
C19H39NO2
CAS Number:
1407154-31-7
Molecular Weight:
313.52
MDL number:
MFCD28143605
UNSPSC 코드:
12352211
NACRES:
NA.25

₩228,680

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청

양식

powder

포장

pkg of 1 × 5 mg (860478P-5mg)

제조업체/상표

Avanti Research™ - A Croda Brand

지질 유형

sphingolipids

배송 상태

dry ice

저장 온도

−20°C

SMILES string

CCCCCCCCCCCCC/C=C(C)\[C@@H](O)[C@@H](N)CO

InChI

1S/C19H39NO2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-17(2)19(22)18(20)16-21/h15,18-19,21-22H,3-14,16,20H2,1-2H3/b17-15-/t18-,19+/m0/s1

InChI key

LMJPKTKGCMCPGM-PIIWLPLESA-N

일반 설명

cis-4-methylsphingosine (cis-4M-Sph) is a methyl-branched sphingosine analog.[1][2]

생화학적/생리학적 작용

cis-4-methylsphingosine (cis-4M-Sph) modulates sphingosine 1 phosphate (S1P) receptor through its metabolite cis-4-methylsphingosine-1-phosphate (cis-4M-S1P). This leads to S1P receptor internalization and desensitization.[1] cis-4M-Sph shows an inhibitory effect on serine palmitoyltransferase activity.[2]

포장

5 mL Amber Glass Screw Cap Vial (860478P-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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시험 성적서(COA)

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문서 라이브러리 방문

Michael Ter Braak et al.
Biochemical pharmacology, 81(5), 617-625 (2010-12-18)
Sphingosine-1-phosphate (S1P) acts as high affinity agonist at specific G-protein-coupled receptors, S1P(1-5), that play important roles e.g. in the cardiovascular and immune systems. A S1P receptor modulating drug, FTY720 (fingolimod), has been effective in phase III clinical trials for multiple
G van Echten-Deckert et al.
The Journal of biological chemistry, 272(25), 15825-15833 (1997-06-20)
The effect of six different structurally modified sphingosine analogues on biosynthesis of sphingolipids was studied in primary cultured murine cerebellar neurons. Treatment of cells with cis-4-methylsphingosine at micromolar levels resulted in a markedly decreased sphingolipid biosynthesis, whereas the other compounds
Wenzheng Xia et al.
Molecular medicine reports, 16(5), 7039-7047 (2017-09-14)
Mesenchymal stem cell (MSC)‑based therapies have demonstrated efficacy in animal models of cardiovascular diseases. However, MSCs decrease in quantity and quality with age, which reduces their capacity for damage repair. Long noncoding (lnc) RNAs regulate gene transcription and the fate
Qun Li et al.
International journal of molecular medicine, 42(2), 1054-1063 (2018-05-12)
Stroke is the second most common cause of death worldwide, and thus, it imposes great financial burdens on both individuals and society. Mesenchymal stem cell (MSC) therapy is a promising approach for ischemic brain injury. However, MSC treatment potential is

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