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Merck
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주요 문서

810230P

Avanti

C6-NBD Safingol

Avanti Research™ - A Croda Brand 810230P, powder

동의어(들):

N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-L-threo-sphinganine

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C30H51N5O6
CAS Number:
114301-98-3
Molecular Weight:
577.76
UNSPSC 코드:
12352211

분석

>99% (TLC)

양식

powder

포장

pkg of 1 × 50 μg (810230P-50ug)

제조업체/상표

Avanti Research™ - A Croda Brand 810230P

배송 상태

dry ice

저장 온도

−20°C

일반 설명

Safingol belongs to the lysosphingolipid class and is the synthetic L-threo-stereoisomer of (D-erythro-) sphinganine.[1][2]

생화학적/생리학적 작용

Safingol, a competitive inhibitor of sphingosine kinase 1, exhibits anticancer activity. It is known to increase antitumor activity of cisplatin in xenograft experiments.[3]

포장

5 mL Amber Glass Screw Cap Vial (810230P-50ug)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Jesse Coward et al.
Autophagy, 5(2), 184-193 (2008-12-23)
Safingol, the synthetic L-threo-stereoisomer of endogenous (D-erythro-) sphinganine, is an inhibitor of protein kinase C and sphingosine kinase in vitro, and in some cell types has been implicated in ceramide generation and induction of apoptosis. Utilizing electron microscopy, acridine orange
Mark A Dickson et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 17(8), 2484-2492 (2011-01-25)
Sphingosine 1-phosphate (S1P) is an important mediator of cancer cell growth and proliferation. Production of S1P is catalyzed by sphingosine kinase 1 (SphK). Safingol, (l-threo-dihydrosphingosine) is a putative inhibitor of SphK. We conducted a phase I trial of safingol (S)
Synthesis of threo-beta-aminoalcohols from aminoaldehydes via chelation-controlled additions. Total synthesis of l-threo sphingosine and safingol
Jung ME and Yi SW
Tetrahedron Letters, 53(32), 4216-4220 (2012)

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