700078P

7α,25-dihydroxycholesterol-d6

Avanti Research^™ - A Croda Brand

• 동의어(들): 26,26,26,27,27,27-hexadeutero-7α,25-dihydroxycholesterol ; 111117
• 실험식(Hill 표기법): C₂₇H₄₀D₆O₃
• CAS Number: 2260669-11-0
• Molecular Weight: 424.69
• UNSPSC 코드: 41141804
• NACRES: NA.25

속성

• 설명: 7α,25-dihydroxycholesterol-d6
• 분석: >99% (TLC)
• 형태: powder
• 포장: pkg of 1 × 1 mg (700078P-1mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: [H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=C[C@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC(O)(C([2H])([2H])[2H])C([2H])([2H])[2H]

설명

일반 설명

7α,25-dihydroxycholesterol (7α,25-OHC) is synthesized by the hydroxylation of cholesterol by the action of enzyme cholesterol 25-hydroxylase (CH25H) and cytochrome P450, family 7, subfamily b, polypeptide 1 (CYP7B1). The catabolic breakdown of 7α,25-OHC to bile acid precursors is catalyzed by the enzymes hydroxy-Δ-5-steroid dehydrogenase, 3β- and steroid Δ-isomerase 7 (HSD3B7). 7α,25-dihydroxycholesterol-d6 is the deuterated form of 7α,25-dihydroxycholesterol.

애플리케이션

7α,25-dihydroxycholesterol-d6 has be used as an internal standard in liquid chromatography electrospray ionization tandem mass spectrometric (LC–ESI-MS/MS) analysis of human plasma.

생화학적/생리학적 작용

7α,25-dihydroxycholesterol (7α,25-OHC) serves as an endogenous ligand for G-protein-coupled receptor 183 (GPR183) or Epstein-Barr virus-induced gene 2 (EBI2). It plays a key role in the migration of type 3 innate lymphoid cells (ILC3) in the small intestine and colon. 7α,25-OHC mediates immune cell migration functionality by their chemoattractant property. Inhibition of 7α,25-OHC synthesis leads to impairment in the migration of B cells.

포장

5 mL Amber Glass Screw Cap Vial (700078P-1mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• Flash Point (°F): No data available
• Flash Point (°C): No data available