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700061P

Avanti

24(S)-hydroxycholesterol

Avanti Research™ - A Croda Brand

동의어(들):

5-cholestene-3β,24-diol; 24-hydroxycholest-5-en-3-ol

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크기 선택

1 MG
₩649,600
5 MG
₩2,636,666

₩649,600

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청
모든 사진(2)

크기 선택

보기 변경
1 MG
₩649,600
5 MG
₩2,636,666

About This Item

실험식(Hill 표기법):
C27H46O2
CAS Number:
474-73-7
Molecular Weight:
402.65
MDL number:
MFCD03695560
UNSPSC 코드:
12352211
NACRES:
NA.25

₩649,600

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청

설명

cholest-5-ene-3β,24(S)-diol

분석

>99% (TLC)

양식

powder

포장

pkg of 1 × 1 mg (700061P-1mg)
pkg of 1 × 5 mg (700061P-5mg)

제조업체/상표

Avanti Research™ - A Croda Brand

배송 상태

dry ice

저장 온도

−20°C

SMILES string

O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CC[C@H](O)C(C)C)C)(CC3)C)CC=C2C1)C

InChI

1S/C27H46O2/c1-17(2)25(29)11-6-18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20+,21+,22-,23+,24+,25+,26+,27-/m1/s1

InChI key

IOWMKBFJCNLRTC-XWXSNNQWSA-N

일반 설명

24(S)-hydroxycholesterol (24HC) is synthesized from cholesterol in brain dendrites by the action of enzyme cholesterol 24-hydroxylase (CYP46A1).[1] It is catabolized to bile acids in the liver.[2]

애플리케이션

24(S)-hydroxycholesterol has been used as an internal standard:
  • in ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)[3]
  • in liquid chromatography with tandem mass spectrometry (LC-MS/MS) for the quantification of 27-hydroxycholesterol from colorectal tumor samples[4]
  • for quantification of human plasma sterols by liquid chromatography with tandem mass spectrometry (LC MS/MS)[5]

생화학적/생리학적 작용

24(S)-hydroxycholesterol (24HC) elevated levels are reported in liver inflammation and fibrosis.[2] It is a N-methyl-D-aspartate receptor (NMDAR) modulator.[1] The levels of 24HC are potential indicators of brain development as well as pathology including Alzheimer′s disease (AD) and multiple sclerosis.[6] Polymorphism in the cholesterol 24-hydroxylase (CYP46A1) gene leads to elevated 24HC levels and toxicity. 24HC is a mediator of apoptosis and necroptosis.[7] Elevated levels of 24HC are reported in liver inflammation and fibrosis.[2]

포장

5 mL Amber Glass Screw Cap Vial (700061P-1mg)
5 mL Amber Glass Screw Cap Vial (700061P-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

또한 이 제품과 함께 일반적으로 구입

제품 번호
설명
가격

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation
Sun MY, et al.
Testing, 12(3) (2017)
Diverse functions of 24 (S)-hydroxycholesterol in the brain
Noguchi N, et al.
Biochemical and Biophysical Research Communications, 446(3), 692-696 (2014)
24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation
Sun MY, et al.
PLoS ONE, 12(3) (2017)
A validated liquid chromatography-tandem mass spectrometry method for the quantitative determination of 4beta-hydroxycholesterol in human plasma
van de Merbel NC, et al.
Journal of Pharmaceutical and Biomedical Analysis, 55(5), 1089-1095 (2011)
Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum
Bandaru VVR and Haughey NJ
BMC Neuroscience, 15(1), 137-137 (2014)
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