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700027P

Avanti

7α-hydroxy-3-oxo-4-cholestenoic acid

Avanti Research™ - A Croda Brand

동의어(들):

(25R)-cholest-4-en-26-oic acid, 7α-hydroxy-3-oxo

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크기 선택

1 MG
₩726,537

₩726,537

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청
모든 사진(2)

크기 선택

보기 변경
1 MG
₩726,537

About This Item

실험식(Hill 표기법):
C27H42O4
CAS Number:
1246298-65-6
Molecular Weight:
430.62
MDL number:
MFCD00042919
UNSPSC 코드:
12352211
NACRES:
NA.25

₩726,537

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청

분석

>99% (TLC)

양식

powder

포장

pkg of 1 × 1 mg (700027P-1mg)

제조업체/상표

Avanti Research™ - A Croda Brand

배송 상태

dry ice

저장 온도

−20°C

일반 설명

7α-Hydroxy-3-oxo-4-cholestenoic acid (7-HOCA) is synthesized extrahepatically from cholesterol.[1] The enzyme oxysterols-7α-hydrolase (CYP7B1) acts on precursor 27-hydroxycholesterol (27-OHC) to generate 7-HOCA.[2]. 7-HOCA is catabolized in the liver.[3]

애플리케이션

7α-hydroxy-3-oxo-4-cholestenoic acid has been used as an analyte in ultra-high-performance liquid chromatography (UHPLC) system.[4]

생화학적/생리학적 작용

The levels of 7α-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA) in cerebrospinal fluid are not correlated to neurodegeneration but may serve as a diagnostic marker to trace blood-brain barrier integrity.[1]

포장

5 mL Amber Glass Screw Cap Vial (700027P-1mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation
Shafaati M, et al.
Journal of Lipid Research, 52(5), 1004-1010 (2011)
Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation
Testa G, et al.
Redox Biology, 10, 24-33 (2016)
Cholestenoic acid is a prognostic biomarker in acute respiratory distress syndrome
Madenspacher JH, et al.
The Journal of Allergy and Clinical Immunology, 143(1), 440-442 (2019)
7 ? -hydroxy-3-oxo-4-cholestenoic acid in cerebrospinal fluid reflects the integrity of the blood-brain barrier
Saeed A, et al.
Journal of Lipid Research, 55(2), 313-318 (2014)
Vladimiro Cardenia et al.
Biochimie, 153, 99-108 (2018-08-06)
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