131305P

Sulfatides (Brain)

Avanti Research^™ - A Croda Brand

• 동의어(들): Cerebroside sulfates; Mono-Sulfo Galactosyl(β) Ceramide (d18:1/24:0); 3-O-sulfo-β-D-C24-galactosylceramide (ammonium salt)
• CAS Number: 383906-24-9
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 설명: Sulfatides (Brain, Porcine) (ammonium salt)
• 분석: >99% (TLC)
• 양식: powder
• 포장: pkg of 1 × 10 mg (131305P-10mg); pkg of 1 × 25 mg (131305P-25mg); pkg of 1 × 5 mg (131305P-5mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand
• 지질 유형: sphingolipids
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: [H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](OS([O-])(=O)=O)[C@H]([C@H]1CO)O.[NH4+]
• InChI: 1S/C48H93NO11S.H3N/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-44(52)49-41(42(51)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2)40-58-48-46(54)47(60-61(55,56)57)45(53)43(39-50)59-48;/h35,37,41-43,45-48,50-51,53-54H,3-34,36,38-40H2,1-2H3,(H,
• InChI key: DVNDZUUWWJPMSI-RYBIKTNWSA-N

설명

일반 설명

Sulfatides are majorly present in the brain and plasma membrane, especially in the outer leaflet. They are anionic sulfoglycolipids synthesized by oligodendrocytes and are the prime component of myelin sheath.[1] It constitutes 4 -7% weight of the myelin lipid.[2] Sulfatides are also associated with non-neural tissues including gall bladder, colon and kidney.[1] In the Golgi, 3′-phosphoadenosine5′phosphosulfate:cerebrosidesulfo transferase mediates the synthesis of sulfatides by 3-O-sulfation of the galactosylceramide. Lysosomes are the catabolism site for sulfatides, wherein arylsulfatase A mediates their breakdown.[1]

This Natural Lipid is a mixture, and the structure shown above is only representative of one possible structure present in the product. Refer to chart for average fatty acid distribution.

애플리케이션

Sulfatides (Brain) has been used:

• as a lipid standard in electrospray ionization (ESI)-MS/MS analysis[3], as an anionic amphiphile for large unilamellar vesicles (LUVs) preparation[4]
• to test its myelin-associated axon growth inhibition functionality in retinal ganglion cells[2]
• as a calibrant in tandem mass spectrometry to quantify mouse brain myelin samples[5]

생화학적/생리학적 작용

Elevated sulfatides levels are implicated in renal, ovarian and adenocarcinoma. Accumulation of sulfatides in events of arylsulfatase A enzyme deficiency leads to metachromatic leukodystrophy, a lysosomal storage disease.[1] Sulfatide is a myelin-associated inhibitor of axon growth and is implicated in the axon regenerative failure.[2] It is a multifunctional sulfolipid, which plays a key role in immune response and insulin secretion. It binds to fibrinogen and elicits anticoagulant activity. Sulfatides are elevated in Parkinson′s disease and is a target for nervous disorder treatment. Sulfatideis also an inhibitor of oligodendrocyte differentiation. Sulfatides are utilized by bacteria for their adherence into host cells.[6] They are responsible for the inflammatory responses in chronic central nervous system illness.[7]

포장

5 mL Amber Glass Screw Cap Vial (131305P-10mg)

5 mL Amber Glass Screw Cap Vial (131305P-25mg)

5 mL Amber Glass Screw Cap Vial (131305P-5mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids