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Merck
모든 사진(1)

문서

930520

Sigma-Aldrich

Pomalidomide-PEG2-C2-NH2 hydrochloride

≥95%

동의어(들):

1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-(2-aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-[[2-[2-(2-Aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C19H24N4O6 · xHCl
CAS Number:
2245697-87-2
Molecular Weight:
404.42 (free base basis)
MDL number:
MFCD32263424
UNSPSC 코드:
12352101
NACRES:
NA.21

ligand

pomalidomide

Quality Level

100

분석

≥95%

형태

powder

작용기

amine

저장 온도

2-8°C

SMILES string

O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCOCCOCCN)=CC=C3)=O)=O

관련 카테고리

애플리케이션

Pomalidomide-PEG2-C2-NH2 hydrochloride is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Allows rapid conjugation with carboxyl linkers due to the presence of an amine group via peptide coupling reactions. It is also active for linker attachment via reductive amination, and a basic building block for development of a protein degrader library.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

기타 정보

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

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