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Merck
모든 사진(1)

주요 문서

924474

Sigma-Aldrich

Hyaluronic Acid

Low Viscosity, Low endotoxin

동의어(들):

3D bioprinting, HA, Hyaluronan

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모든 사진(1)

About This Item

UNSPSC 코드:
12352201
NACRES:
NA.23
가격 및 재고 정보를 현재 이용할 수 없음 고객지원팀으로 연락바랍니다.

Quality Level

100

양식

(powder or chunk(s) or fibers)

불순물

<10 CFU/g Bioburden
<100 EU/g Endotoxin

색상

white to off-white

적합성

conforms to structure for NMR

저장 온도

2-8°C

관련 카테고리

일반 설명

Hyaluronic acid (HA) is a linear polysaccharide of alternating D-glucuronic acid, and N-acetyl-D-glucosamine found in the extracellular matrix. HA is commonly chemically modified to form covalently crosslinked hydrogels. Other properties of HA include cell surface receptors CD44 and RHAMM recognition and degradation via hyaluronidases.

애플리케이션

HA is increasingly used for the following biomedical applications:
  • Cell migration
  • Angiogenesis
  • Viability
  • Proliferation

Our low endotoxin HA is tested for both endotoxin (< 100 EU/g) and bioburden (< 10 CFU/g) levels, so you can choose which material is right for your research.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
MKCW6195
MKCW4277
MKCW0813
MKCV7589
MKCV4310

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COA 검색

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문서 라이브러리 방문

Xian Xu et al.
Soft matter, 8(12), 3280-3294 (2012-03-16)
Hyaluronic acid (HA) is one of nature's most versatile and fascinating macromolecules. Being an essential component of the natural extracellular matrix (ECM), HA plays an important role in a variety of biological processes. Inherently biocompatible, biodegradable and non-immunogenic, HA is
Federica Camin et al.
Journal of agricultural and food chemistry, 58(1), 570-577 (2009-12-17)
H, C, and O stable isotope ratios and the elemental profile of 267 olive oils and 314 surface waters collected from 8 European sites are presented and discussed. The aim of the study was to investigate if olive oils produced
Tracey J Brown
Current pharmaceutical biotechnology, 9(4), 253-260 (2008-08-12)
Despite advances in chemotherapeutic regimens, the treatment of metastatic cancer remains a challenge. A key problem with chemotherapy drugs is nonspecific drug distribution, resulting in low tumor concentrations and systemic toxicity. The holy grail of clinical cancer research has been
Kevin T Dicker et al.
Acta biomaterialia, 10(4), 1558-1570 (2013-12-24)
Hyaluronan (HA) is a linear polysaccharide with disaccharide repeats of d-glucuronic acid and N-acetyl-d-glucosamine. It is evolutionarily conserved and abundantly expressed in the extracellular matrix (ECM), on the cell surface and even inside cells. Being a simple polysaccharide, HA exhibits
Jason A Burdick et al.
Advanced materials (Deerfield Beach, Fla.), 23(12), H41-H56 (2011-03-12)
Hyaluronic acid (HA), an immunoneutral polysaccharide that is ubiquitous in the human body, is crucial for many cellular and tissue functions and has been in clinical use for over thirty years. When chemically modified, HA can be transformed into many

문서

Rational Design of ECMs Toward Cancer Immunotherapy

Engineered ECMs enhance immune therapy in cancer treatment by supporting cells and tissues and modulating immune response. They improve immune cell maturation, expansion, and regulation through biomaterial manipulation, acting as frameworks or carriers for enhanced tumor immunotherapy.

질문

1–4 / 4 질문  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 답변

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 답변

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. what MW range is the HA in this poduct?

    1 답변

    1. The molecular weight of this product is not determined. However, historical data suggests batches typically have a Mn (molecular number) around 20-40kDa.

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  4. How can this product best be reconstituted for surface coating TC substrates?

    1 답변

    1. Unfortunately, this product is not tested for solubility. However, according to the literature, Hyaluronic acid is soluble in water. Dissolve in cold water and shake slowly until the hyaluronic acid is dissolved completely. Please note this has not been validated internally.

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