906298

3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine

• 동의어(들): Probe building block for photoaffinity labeling, Suzuki-Miyaura-compatible multifunctional photo probe building block, Trifluoromethyl diazirine aryl bromide
• 실험식(Hill 표기법): C₈H₄BrF₃N₂
• CAS Number: 952143-02-1
• Molecular Weight: 265.03
• MDL number: MFCD31667367
• UNSPSC 코드: 12352101
• NACRES: NA.22

속성

• 분석: ≥95%
• 양식: liquid
• 반응 적합성: reagent type: cross-linking reagent
• 저장 온도: 2-8°C
• SMILES string: BrC1=CC=C(C2(N=N2)C(F)(F)F)C=C1
• InChI: 1S/C8H4BrF3N2/c9-6-3-1-5(2-4-6)7(13-14-7)8(10,11)12/h1-4H
• InChI key: YBEXZCGWGWNLQQ-UHFFFAOYSA-N

설명

애플리케이션

3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine is a Suzuki-Miyaura (S−M)-compatible building block tailored for the design of photoaffinity probes (PAPs). Photoaffinity labeling (PAL) is of growing interest in chemical biology and drug discovery research for use in protein profiling; covalent inhibitors; protein-protein interactions and complexes; and target engagement, identification, or validation studies. Diazirines are desirable photoactivable groups for chemical probes; however, their installation is not always straightforward. In response, diazirine-tolerant S-M coupling conditions were developed by Ichiishi, et al, using 3-(4-bromophenyl)-3-(trifluoromethyl)-3H-diazirine and shown to be efficient and scalable with minimal perturbation of the diazirine.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

기타 정보

Reducing Limitation in Probe Design: The Development of a Diazirine-Compatible Suzuki-Miyaura Cross Coupling Reaction

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable