857270

(+)-Cinchonine

85%

• 동의어(들): Cinchonine monohydrochloride dihydrate, NSC 6176
• 실험식(Hill 표기법): C₁₉H₂₂N₂O
• CAS Number: 118-10-5
• Molecular Weight: 294.39
• Beilstein: 89689
• EC Number: 204-234-6
• MDL number: MFCD00064372
• UNSPSC 코드: 12352104
• PubChem Substance ID: 24888435
• NACRES: NA.22

속성

• 분석: 85%
• 형태: solid
• 광학 활성: [α]23/D +228°, c = 0.5 in ethanol
• mp: 258-260 °C (lit.)
• SMILES string: [H][C@@]12CCN(C[C@H]1C=C)[C@]([H])(C2)[C@@H](O)c3ccnc4ccccc34
• InChI: 1S/C19H22N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h2-7,9,13-14,18-19,22H,1,8,10-12H2/t13-,14-,18+,19-/m0/s1
• InChI key: KMPWYEUPVWOPIM-QAMTZSDWSA-N

설명

일반 설명

(+)-Cinchonine, one of the alkaloids found in the barks of cinchona tree, is mainly used in the treatment of malaria. It belongs to the monoclinic crystal system and P2₁ space group. The solubility of cinchonine can be improved by the formation of inclusion complexes with cyclodextrins.

애플리케이션

(+)-Cinchonine, in the presence of lithium diisopropylamide (LDA) forms a complex, which can catalyze the asymmetric conjugate addition of benzyl- and alkylphosphonates to aromatic and heteroaromatic nitroalkenes to form the corresponding adducts.

기타 정보

remainder dihydrocinchonine

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H317
• 예방조치 성명서: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Skin Sens. 1A
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves