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Merck
모든 사진(1)

주요 문서

804339

Sigma-Aldrich

4-iodo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-Benzeneacetamide

동의어(들):

AbaR inhibitor, TraR

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About This Item

실험식(Hill 표기법):
C12H12INO3
CAS Number:
Molecular Weight:
345.13
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.22

양식

solid

저장 온도

−20°C

SMILES string

O=C(OCC1)[C@@]1([H])NC(CC2=CC=C(I)C=C2)=O

InChI

1S/C12H12INO3/c13-9-3-1-8(2-4-9)7-11(15)14-10-5-6-17-12(10)16/h1-4,10H,5-7H2,(H,14,15)/t10-/m0/s1

InChI key

IMJUHEKUNKCNGB-JTQLQIEISA-N

애플리케이션

PHL is a strong inhibitor of several LuxR-type receptors, including LuxR from V. fischeri,[1] TraR from A. tumefaciens,[2] the putative LuxR-type receptor from A. baumannii – AbaR,[3] and RhlR from P. aeruginosa.[4] This compound represents a good choice for initial testing of LuxR-type receptor inhibition.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Michael A Welsh et al.
Journal of the American Chemical Society, 137(4), 1510-1519 (2015-01-13)
The opportunistic pathogen Pseudomonas aeruginosa uses three interwoven quorum-sensing (QS) circuits-Las, Rhl, and Pqs-to regulate the global expression of myriad virulence-associated genes. Interception of these signaling networks with small molecules represents an emerging strategy for the development of anti-infective agents
Grant D Geske et al.
ACS chemical biology, 2(5), 315-319 (2007-05-08)
Bacteria monitor their population densities using low-molecular-weight ligands in a process known as quorum sensing. At sufficient cell densities, bacteria can change their mode of growth and behave as multicellular communities that play critical roles in both beneficial symbioses and
Danielle M Stacy et al.
ACS chemical biology, 7(10), 1719-1728 (2012-08-03)
Many bacterial pathogens use quorum sensing (QS) to control virulence. As a result, the development of methods to intercept QS has attracted significant interest as a potential anti-infective therapy. Acinetobacter baumannii has emerged as a pan-drug-resistant pathogen and displays a
Grant D Geske et al.
Journal of the American Chemical Society, 129(44), 13613-13625 (2007-10-12)
Bacteria use a language of low molecular weight ligands to assess their population densities in a process called quorum sensing. This chemical signaling process plays a pivotal role both in the pathogenesis of infectious disease and in beneficial symbioses. There

관련 콘텐츠

We study quorum sensing, how bacteria sense their density. Synthesized compounds modulate pathways, aiding research on infections in various hosts.

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