추천 제품
분석
≥98.0%
양식
solid
반응 적합성
reaction type: click chemistry
reagent type: ligand
reaction type: Staudinger Reaction
mp
52-55 °C
작용기
phosphine
저장 온도
2-8°C
SMILES string
B.CC(=O)SCP(c1ccccc1)c2ccccc2
InChI
1S/C15H15OPS.BH3/c1-13(16)18-12-17(14-8-4-2-5-9-14)15-10-6-3-7-11-15;/h2-11H,12H2,1H3;1H3
InChI key
MXPNVFCCEGQGEN-UHFFFAOYSA-N
애플리케이션
- Traceless Staudinger ligation reagent with borane protecting group.
- The borane group stabilizes the phosphine against oxidation and can be easily removed with mild basic or acidic conditions to yield the active phosphine.[1]
- After reaction with an azide, the phosphine is eliminated in the presence of water to yield a native amide bond.[2]
- Used in the synthesis of cyclic peptides.[2]
포장
Bottomless glass bottle. Contents are inside inserted fused cone.
법적 정보
Sold under license for research and development purposes only. US Patent 6,974,884 and related patents apply
관련 제품
신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
Matthew B Soellner et al.
The Journal of organic chemistry, 67(14), 4993-4996 (2002-07-06)
The Staudinger ligation of peptides with a C-terminal phosphinothioester and N-terminal azide is an emerging method in protein chemistry. Here, the first Staudinger ligations of nonglycyl azides are reported and shown to proceed both in nearly quantitative yield and with
Michaela Mühlberg et al.
Bioorganic & medicinal chemistry, 18(11), 3679-3686 (2010-05-15)
The traceless Staudinger ligation has recently found various applications in the field of peptide synthesis and modification, including immobilization and cyclization strategies. In this report, we utilize the traceless Staudinger ligation in the formation of amide bonds, which allows the
관련 콘텐츠
Raines lab innovations include traceless Staudinger ligation and DTBA reagent, advancing chemical biology research with Sigma-Aldrich.
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.
