661082

2,4-Difluoropyrimidine

97%

• 실험식(Hill 표기법): C₄H₂F₂N₂
• CAS Number: 2802-61-1
• Molecular Weight: 116.07
• MDL number: MFCD04972830
• UNSPSC 코드: 12352100
• PubChem Substance ID: 24884500
• NACRES: NA.22

속성

• 분석: 97%
• refractive index: n20/D 1.432
• bp: 118-120 °C
• density: 1.359 g/mL at 25 °C
• 작용기: fluoro
• SMILES string: Fc1ccnc(F)n1
• InChI: 1S/C4H2F2N2/c5-3-1-2-7-4(6)8-3/h1-2H
• InChI key: JZSYSXZDIQUOGP-UHFFFAOYSA-N

설명

애플리케이션

2,4-Difluoropyrimidine can be used as a starting material to synthesize:

• 3-Pyrimidin-4-yl-oxazolidin-2-one derivatives as mutant isocitrate dehydrogenase (IDH₁) inhibitors.[1]
• N,N′-(1,4-phenylenebis(methylene))bis(2-fluoropyrimidin-4-amine) as chemokine receptor type 4 antagonists.[2]

안전성 정보

• 픽토그램: GHS02,GHS05,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H226,H302,H315,H318,H335
• 예방조치 성명서: P210 - P233 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point (°F): 106.0 °F - closed cup
• Flash Point (°C): 41.1 °C - closed cup
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter