651753

2-Chloro-5-fluoropyrimidine

97%

• 실험식(Hill 표기법): C₄H₂ClFN₂
• CAS Number: 62802-42-0
• Molecular Weight: 132.52
• MDL number: MFCD03788197
• UNSPSC 코드: 12352100
• PubChem Substance ID: 24883860
• NACRES: NA.22

속성

• 분석: 97%
• refractive index: n20/D 1.503 (lit.)
• density: 1.439 g/mL at 20 °C (lit.)
• SMILES string: Fc1cnc(Cl)nc1
• InChI: 1S/C4H2ClFN2/c5-4-7-1-3(6)2-8-4/h1-2H
• InChI key: AGYUQBNABXVWMS-UHFFFAOYSA-N

설명

애플리케이션

2-Chloro-5-fluoropyrimidine can be used as a starting material for the preparation of:

• 5-fluoro-2-amino pyrimidines by reacting with various amines in the presence of K₂CO₃, via C-N bond forming reaction.
• 2-chloro-5-(5-fluoropyrimidin-2-yl)benzoic acid, an intermediate, which is used in the synthesis of benzamide scaffolds as potent antagonists against P2X7 receptors.
• 5-fluoro-2-cyano pyrimidine, a key intermediate used for the synthesis of 5-chloro-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine, as a potent inhibitor of the JAK2 kinase.

안전성 정보

• 픽토그램: GHS05,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H314
• 예방조치 성명서: P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Acute Tox. 4 Oral - Skin Corr. 1B
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flash Point (°F): 149.0 °F - closed cup
• Flash Point (°C): 65 °C - closed cup
• 개인 보호 장비: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter