417246

Dimethylzinc solution

1.0 M in heptane

• 동의어(들): Dimethylzinc
• Linear Formula: (CH₃)₂Zn
• CAS Number: 544-97-8
• Molecular Weight: 95.46
• Beilstein: 3587195
• MDL number: MFCD00014854
• UNSPSC 코드: 12352103
• PubChem Substance ID: 24866132
• NACRES: NA.22

속성

• 양식: liquid
• Quality Level: 100
• 농도: 1.0 M in heptane
• bp: 44-46 °C
• density: 0.724 g/mL at 25 °C
• SMILES string: C[Zn]C
• InChI: 1S/2CH3.Zn/h2*1H3;
• InChI key: AXAZMDOAUQTMOW-UHFFFAOYSA-N

설명

일반 설명

Dimethylzinc (Zn(CH₃)₂) is a methylating reagent used to prepare methylated organic compounds as well as organometallic compounds containing methyl groups [1][2]. It is also utilized as a reagent to prepare amino alcohols, oximes, and hydrazones from arylamines, alkoxyamines, and dialkylhydrazines respectively, by radical addition reaction in the presence of air and THF.[3]

Dimethylzinc is a diorganozinc reagent and nucleophile used in the synthesis of propargylic amines. [4][3]

애플리케이션

Dimethylzinc solution can be used as:

• A catalyst with nickel for the stereoselective C−2 alkenylation and dialkenylation of pyridine derivatives by alkynes to give monoalkenylation products.[5]
• A reagent with aldehydes and 2-methoxyaniline for the synthesis of enantioselective alkyl and aralkyl secondary amines via one-pot three-component coupling reaction in the presence of zirconium tetraisopropoxide.[6]
• A methylating reagent for methylation of fluoroalkylated pyruvates in the presence of copper/chiral diphosphine catalyst.[7]

안전성 정보

• 픽토그램: GHS02,GHS08,GHS05,GHS07,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H225,H250,H261,H304,H314,H336,H410
• 예방조치 성명서: P210 - P231 + P232 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P370 + P378
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Pyr. Liq. 1 - Skin Corr. 1B - STOT SE 3 - Water-react 2
• 표적 기관: Central nervous system
• Storage Class Code: 4.2 - Pyrophoric and self-heating hazardous materials
• WGK: WGK 3
• Flash Point (°F): 30.2 °F - closed cup
• Flash Point (°C): -1 °C - closed cup
• 개인 보호 장비: Faceshields, Gloves, Goggles